Table 2.
Grading of mouse glomeruli histopathology in each treatment cohort
| Cfh−/− | CFH-H/0 | CFH-H/H |
Cfh−/− AAV12tCFH |
Cfh−/− AAV18tCFH |
Cfh−/− AAVFHL-1 |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||||
| ID | Grade* | ID | Grade | ID | Grade | ID | Grade | ID | Grade | ID | Grade |
|
| |||||||||||
| 170 | III | 393 | II | 007 | 0 | 2954 | 0 | 2971 | II | 2966 | I |
| 390 | III | 007 | II | 008 | 0 | 2955 | 0 | 2972 | II | 2967 | 0 |
| 22 | I | 2957 | I | 2973 | II | 2968 | II | ||||
| 23 | 0 | 2958 | I | 2974 | 0 | ||||||
| 2959 | I | 2975 | I | ||||||||
| 2960 | I | ||||||||||
| 2961 | I | ||||||||||
| 2962 | II | ||||||||||
| 2964 | I | ||||||||||
| 2965 | I | ||||||||||
*
In each treatment cohort, images of mouse glomerulus histopathology were graded according to the procedure described in the methods. Holistic scores were assigned to each animal according to the average grade of its glomerular histopathology.