Figure 4. Early Life Unpredictability Is Associated with Task-Based Functional Connectivity of the Right Amygdala in a Sex-Specific Manner.

A) Synthesized examples of raw signals occurring in a Psychophysiological Interaction (PPI, upper left panel) and their task-dependent correlation structure (upper right panel). B) Empirical scatter plot showing sex-specific associations between early-life unpredictability (QUIC) and PPI-based task-dependent correlations. In a sex-stratified analysis, QUIC scores were significantly (p<0.05) associated with PPI measures in both sexes but in opposing directions. C) QUIC by sex interactions are depicted across the observed amygdala and hippocampus ROIs.