Fig. 4. Impact of Macrodissection on signature scores.

Three samples were profiled across three different sample conditions: tumor macrodissected tissue (T), normal macrodissected tissue (N) and non-macrodissected tissue (PM). As expected, normal tissue can result in large changes to the signature score, which can be seen in non-macrodissected tissues as well. For instance, the 12CK GES score for Normal tissue from sample 1 is much higher however there is elevated signal in the PM sample as well, whereas the differences in sample 3 (N,T,PM) are small.