Total 10-year costs of treatment sequences by first two lines of treatment in patients without TP53 aberration. ACAL: acalabrutinib, ACAL + O: acalabrutinib in combination with obinutuzumab, BR: bendamustine in combination with rituximab, CAD: Canadian dollars, CLB + O: chlorambucil in combination with obinutuzumab, CLB + R: chlorambucil in combination with rituximab, FCR: fludarabine, cyclophosphamide, rituximab, FR: fludarabine in combination with rituximab, IBRU: ibrutinib, V: venetoclax, VO: venetoclax in combination with obinutuzumab, VR: venetoclax in combination with rituximab. The black horizontal line represents the mean cost of all treatment sequences.