Skip to main content
. 2024 Sep 19;16(18):3193. doi: 10.3390/cancers16183193

Figure 2.

Figure 2

A schematic representation of the PI3 K/AKT, MAPK, and NF-κB pathways involved in the inhibition of expression and activity of MMP-2/9 by polyphenols (created by BioRender). AKT—protein kinase B; ERK—extracellular-signal-regulated kinase; IKK—I kappa B kinase; IKKα—catalytic subunit of IKK; IκBα—inhibitor alpha of nuclear factor-kappa B; GTP—guanosine-5′-triphosphate; MEK—mitogen-activated protein kinase; MMP-2/9—matrix metalloproteinase-2/9 (type IV collagenases); mTOR—mammalian target of rapamycin; NF-κB—nuclear factor-kappa B; PI3 K—phosphatidylinositol 3-kinase; p38 MAPK—p38 mitogen-activated protein kinase; RAS—rat sarcoma, subfamily of small GTPases; RelA—subunit of NF-κB; EGCG—epigallocatechin-3-gallate.