Table 4.
Comparison of neurosteroid levels between slow and fast progressors among ALS patients.
| Biological Variable, Fluid | N | Slow Progressors, Median [IQR] |
N | Fast Progressors, Median [IQR] |
p Value |
|---|---|---|---|---|---|
| Pregnenolone sulfate, CSF (ng/mL) | 22 | 0.0482 [0.0221–0.0530] |
15 | 0.0499 [0.0245–0.0616] |
0.171 |
| Pregnenolone, CSF (ng/mL) | 22 | 0.0606 [0.0329–0.102] |
15 | 0.0662 [0.0380–0.103] |
0.656 |
| Progesterone, CSF (ng/mL) | 22 | 0.0232 [0.0169–0.0319] |
15 | 0.0151 [0.00875–0.0299] |
0.426 |
| 5α-di-hydroprogesterone, CSF (ng/mL) | 22 | 0.0215 [0.0165–0.0238] |
15 | 0.0219 [0.0206–0.0257] |
0.484 |
| Allopregnanolone, CSF (ng/mL) | 19 | 0.00671 [0.00524–0.00880] |
12 | 0.00882 [0.00644–0.00998] |
0.148 |
| Pregnanolone, CSF (ng/mL) | 21 | 0.0216 [0.00648–0.0312] |
15 | 0.0282 [0.00662–0.0329] |
0.610 |
| Testosterone, CSF (ng/mL) | 11 | 0.00923 [0.00821–0.0135] |
6 | 0.0114 [0.0104–0.0141] |
0.171 |