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Mechanisms of action of H2S donors in inflammatory diseases. GYY4137 and DADS inhibit NF-κB pathways and activate the Nrf2/ARE pathway, which inhibits pro-inflammatory cytokines and activates antioxidant pathways, respectively. NaHS activates NF-κB and SRF pathways and activates pro-inflammatory mediators. NaHS also activates antioxidant pathways. FW1256 and ACS-15 also suppress the NF-κB pathway and show anti-inflammatory effects.
