FIG. 7.
Comparison of AST and ALT plasma levels after transduction of liver with [E1−,E3−]AdlacZ or [E1−,E3−,100K−]AdlacZ. A total of 4 × 109 lacZ-forming units of the respective vectors were intravenously injected into mice, and plasma samples were obtained from the animals at the indicated time points (n ≥ 4 at 1 and 3 dpi; n = 6 at 8 dpi). Similar levels of transduction were confirmed for both vectors after X-Gal staining of liver samples derived from the animals (see Fig. 6A and data not shown). Those time points that demonstrated levels of AST or ALT that were significantly different (P < 0.05; determined by two-tailed Student's t test) between the indicated vectors are indicated by an asterisk.