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. 2024 Aug 25;14(9):1058. doi: 10.3390/biom14091058

Figure 2.

Figure 2

Panx1 deletion enhances glucose over fat metabolism in 14-week-old mice. (A) Body weights of all 14-week-old WT (black dots) and Panx1−/− (red dots) mice before separating them into 3 groups. (B) Fat mass of WT and Panx1−/− mice (G1) measured by echoMRI. Serum total cholesterol (C), FFA (D), and TG (E) levels in WT and Panx1−/− mice. Indirect calorimetry allowed the quantification of energy expenditure (F), cumulative food intake (G), cumulative water consumption (H), respiratory exchange ratio (K), and FA oxidation (L) in WT and Panx1−/− mice (mice were housed two per cage; each cage was considered as one pooled sample; N = 6 cages). The active period of mice is indicated in light blue. Ghrelin (I), leptin (J), and FGF21 (N) levels measured by ELISA in serum of WT and Panx1−/− mice. (M) Oral glucose tolerance test and (O) insulin tolerance test of WT (OGTT: N = 29; ITT: N = 20) and Panx1−/− (OGTT: N = 30; ITT: N = 20) mice. Data are shown as individual data points, except for time lines where the number of mice is specified, and expressed as mean ± SEM. * p ≤ 0.05, † p ≤ 0.01, and ‡ p ≤ 0.001.