Table 3.

Cancer recurrence using cox regression.

Characteristics	Univariate			Multivariate
	Hazard Ratio	95% CI	p-Value	Hazard Ratio	95% CI	p-Value
Number of liver tumors at 1st diagnosis
	1.103	1.045–1.163	0.0003	1.095	1.035–1.158	0.0016
Greatest dimension of liver tumor
	1.034	0.954–1.056	0.8781	0.999	0.947–1.054	0.9685
Development of extra-hepatic metastatic disease
No	1.00			1.00
Yes	2.03	1.49–2.78	<0.0001	2.10	1.50–2.93	<0.0001
Development of pulmonary metastasis
No	1.00			1.00
Yes	2.02	1.50–2.72	<0.0001	2.01	1.46–2.93	<0.0001
Liver metastasis recurrence
No	1.00			1.00
Yes	1.37	0.99–1.89	0.0543	1.35	0.96–1.90	0.0866
Multiple of extra-hepatic metastatic site
No	1.00			1.00
Yes	2.09	1.57–2.77	<0.0001	2.16	1.60–2.91	<0.0001
Resection with and without BEV
Chemo-naive	1.00			1.00
Neoadjuvent	1.89	1.27–2.80	0.0018	1.61	1.07–2.42	0.0230
BEV	1.27	0.83–1.95	0.2748	1.07	0.68–1.69	0.7589

Models are all adjusted for age at first diagnosis, gender, and BMI. Significant values are highlighted in bold.