Table 4.
Patient characteristics of desmoplastic vs. non-desmoplastic tumors.
| Desmoplastic | Non-Desmoplastic | p-Value | |
|---|---|---|---|
| n = 110 | n = 148 | ||
| Age at diagnosis, mean (SD) | 62.4 ± 10.22 | 60.57 ± 10.13 | 0.1250 |
| BMI, mean (SD) | 26.80 ± 5.66 | 26.96 ± 4.63 | 0.6221 |
| Mean size of primary tumor, cm (SD) | 13.79 ± 29.14 | 8.03 ± 11.76 | 0.1375 |
| Number of liver tumors at 1st diagnosis, mean (SD) | 3.07 ± 2.35 | 3.41 ± 2.03 | 0.0592 |
| Volume of primary tumor, mean (SD) | 13.79 ± 29.14 | 7.98 ± 11.69 | 0.1372 |
| Greatest dimension of liver tumor cm (SD) | 3.34 ± 2.35 | 3.86 ± 2.78 | 0.0470 |
| Number of liver tumors at initial diagnosis | 3.07 ± 2.35 | 3.40 ± 2.03 | 0.0581 |
| Synchronous presentation | 82 (74.5%) | 101 (68.2%) | 0.2702 |
| Systemic therapy | |||
| Chemo-naive | 25(24.3%) | 27 (19.9%) | 0.4123 |
| Neoadjuvant chemotherapy | 78 (75.7%) | 109 (80.1%) | 0.4123 |
| Neoadjuvant chemotherapy + bevacizumab | 28 (35.9%) | 45 (41.3%) | 0.4565 |
| Metastatic disease | |||
| Development of extrahepatic metastasis | 59 (53.6%) | 106 (73.6%) | 0.0009 |
| Multiple extrahepatic metastatic sites | 36 (33.3%) | 61 (42.1%) | 0.1575 |
| Development of pulmonary metastasis | 51 (46.4%) | 97 (67.8%) | 0.0006 |
| Liver metastatic recurrence | |||
| Yes | 46 (29.5%) | 69 (39.2%) | 0.0375 |
| No | 48 (44.4%) | 45 (30.6%) | |
| Never fully resected | 14 (13.0%) | 33 (22.4%) | |
N—patient number, SD—standard deviation. Categorical variables were compared using Chi-squared test. Significant values are highlighted in bold.