Table 2.

Polysaccharide-based hydrogels applied in wound healing.

Biopolymer(s)	Compositional Attributes	Study	Results/Effects	Reference
Chitosan and collagen	Injectable thermosensitive hydrogels containing three-dimensional mesenchymal stem cell.	In vivo	Proliferation and secretion of paracrine effects, improvement of vascularization and re-epithelialization of the wound.	[116]
Chitosan and pectin	Thermoreversible biopolymer hydrogel.	In vitro	Excellent exudate absorption.	[117]
Sodium alginate and gelatin	Double network hydrogel incorporating self-assembled magnesium nanoparticles mediated by tea polyphenols.	In vivo	Healing of diabetic foot wounds infected with methicillin-resistant Staphylococcus aureus.	[118]
Sodium alginate	Double network hydrogel constructed with dopamine grafted oxidized sodium alginate and polyacrylamide and made by hydrogen bonding and dynamic Schiff cross-linking.	In vitro and in vivo	Self-healing and tissue adhesive hydrogel for wound dressing applications.	[119]
Collagen and starch	Injectable adhesive hydrogel based on starch modified with aldehyde incorporating collagen modified with dopamine.	In vivo	Injectable bioadhesive hydrogel with durable wet tissue adhesion, superior sealing performance, fast self-healing power, shape adaptability, and hemostatic properties.	[120]
Gellan gum and sodium alginate	Composite dressing based on natural polysaccharides and lipid nanoparticles containing antibacterial peptides—nisin.	In vitro	Hydrogel with cytocompatibility and good antimicrobial activity for wound dressing applications.	[94]
Xanthan gum	Hydrogels based on Aloe vera, xanthan gum, natural salicylic acid and allantoin.	In vitro	Natural, biocompatible hydrogels with antibacterial activity developed for dermatological applications.	[106]