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Desmoplakin is composed of an N-terminal globular head domain, a central α-helical rod domain, and a C-terminal tail domain. PKP-2 binds the globular head domain, stabilizing the DSP dimer, while JUP connects DSP to the transmembrane domain of the desmosome. The DSP C-terminal A-B-C plakin repeat domains and the glycine–serine–arginine-rich regions mediate the interactions between the desmosome and the intermediate filaments.
