VHL, pVHL |
von Hippel–Lindau tumour suppressor |
HIFs |
Hypoxia-inducible factors |
ccRCC |
Clear cell renal cell carcinoma |
AHR |
Aryl hydrocarbon receptor |
HIF-1β, ARNT |
Aryl hydrocarbon receptor nuclear translocator |
TCDD |
Dioxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin |
AR |
Androgen receptor |
RB1 |
Retinoblastoma-associated protein |
SAhRMs |
Selective AHR modulators |
bHLH-PAS |
Basic helix–loop–helix-PER-ARNT-SIM transcription factors |
pNETs |
Non-functioning pancreatic neuroendocrine tumours |
RCC |
Renal cell carcinoma |
VCB complex |
Complex formed by pVHL, elongin-B, elongin-C, and Cullin-2 |
ELOB |
Elongin-B |
ELOC |
Elongin-C |
CUL2 |
Cullin-2 |
HIF-1α |
Hypoxia-inducible factor 1-α |
HSP90 |
Heat shock protein 90 |
p23 |
Prostaglandin E synthase 3 |
XAP2 |
AH receptor-interacting protein |
XREs |
Xenobiotic-responsive elements |
DREs |
Dioxin-responsive elements |
Cyp1a |
Cytochrome P450, family 1, subfamily A, polypeptide 1 |
Cyp1b |
Cytochrome P450, family 1, subfamily B, polypeptide 1 |
GSTA1 |
Glutathione S-transferase A1 |
EPHX1 |
Epoxide hydrolase 1 |
PAI2 |
Plasminogen activator inhibitor 2 |
p300 |
Histone acetyltransferase p300 |
CREBBP |
CREB-binding protein |
NCOA1/2/3 |
Nuclear receptor coactivator 1/2/3 |
NRIP1 |
Nuclear receptor-interacting protein 1 |
ER |
Estrogen receptor |
HepaRG |
Human hepatic in vitro line |
MCF7 |
Human breast cancer cell line (Michigan Cancer Foundation-7) |
HepG2 |
Human liver cancer cell line |
786-O |
Human renal cancer cell line |
EGA |
European Genome–Phenome Archive |
TCGA |
The Cancer Genome Atlas |
GEO |
Gene Expression Omnibus |
HR |
Hazard ratio |
PPI |
Protein–protein interaction |
DEGs |
Differentially expressed genes |
GSTA5 |
Glutathione S-transferase A5 |
GSTM2 |
Glutathione S-transferase Mu 2 |
UGT2B11 |
UDP-glucuronosyltransferase 2B11 |
PPIN |
Protein–protein interaction network |
VEGF-A/C |
Vascular endothelial growth factor A/C |
CDK2/4 |
Cyclin-dependent kinase 2/4 |