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. 2024 Sep 5;15(9):1167. doi: 10.3390/genes15091167
VHL, pVHL von Hippel–Lindau tumour suppressor
HIFs Hypoxia-inducible factors
ccRCC Clear cell renal cell carcinoma
AHR Aryl hydrocarbon receptor
HIF-1β, ARNT Aryl hydrocarbon receptor nuclear translocator
TCDD Dioxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin
AR Androgen receptor
RB1 Retinoblastoma-associated protein
SAhRMs Selective AHR modulators
bHLH-PAS Basic helix–loop–helix-PER-ARNT-SIM transcription factors
pNETs Non-functioning pancreatic neuroendocrine tumours
RCC Renal cell carcinoma
VCB complex Complex formed by pVHL, elongin-B, elongin-C, and Cullin-2
ELOB Elongin-B
ELOC Elongin-C
CUL2 Cullin-2
HIF-1α Hypoxia-inducible factor 1-α
HSP90 Heat shock protein 90
p23 Prostaglandin E synthase 3
XAP2 AH receptor-interacting protein
XREs Xenobiotic-responsive elements
DREs Dioxin-responsive elements
Cyp1a Cytochrome P450, family 1, subfamily A, polypeptide 1
Cyp1b Cytochrome P450, family 1, subfamily B, polypeptide 1
GSTA1 Glutathione S-transferase A1
EPHX1 Epoxide hydrolase 1
PAI2 Plasminogen activator inhibitor 2
p300 Histone acetyltransferase p300
CREBBP CREB-binding protein
NCOA1/2/3 Nuclear receptor coactivator 1/2/3
NRIP1 Nuclear receptor-interacting protein 1
ER Estrogen receptor
HepaRG Human hepatic in vitro line
MCF7 Human breast cancer cell line (Michigan Cancer Foundation-7)
HepG2 Human liver cancer cell line
786-O Human renal cancer cell line
EGA European Genome–Phenome Archive
TCGA The Cancer Genome Atlas
GEO Gene Expression Omnibus
HR Hazard ratio
PPI Protein–protein interaction
DEGs Differentially expressed genes
GSTA5 Glutathione S-transferase A5
GSTM2 Glutathione S-transferase Mu 2
UGT2B11 UDP-glucuronosyltransferase 2B11
PPIN Protein–protein interaction network
VEGF-A/C Vascular endothelial growth factor A/C
CDK2/4 Cyclin-dependent kinase 2/4