Table 2.

List of proteins included in the PPIN, with expression levels found upon TCDD exposition and in ccRCC cells.

Node Name	Expression Levels in at Least Three out of the Five Datasets		Kaplan–Meier Analysis		Expression Level Validation with the ccRCC GEO Datasets
Protein ID	TCDD	ccRCC	Overall Survival (p-Value FDR)	LOW Surv. Expression Level
AHR	HIGH	LOW	$5.47\times {10}^{-4}$	LOW	X
ANAPC16	LOW	HIGH	$2.89\times {10}^{-4}$	LOW
AR	HIGH	LOW	$6.24\times {10}^{-11}$	LOW	X
ARNT2	HIGH	HIGH	$2.60\times {10}^{-2}$	LOW
BRCA1	HIGH	LOW	$7.22\times {10}^{-2}$	LOW
CCDC43	HIGH	LOW	$9.01\times {10}^{-5}$	LOW	X
CHMP1A	LOW	LOW	$7.22\times {10}^{-2}$	HIGH
CLEC11A	HIGH	HIGH	$5.20\times {10}^{-3}$	HIGH	X
CYP1B1	LOW	LOW	$1.13\times {10}^{-3}$	HIGH
DDB1	LOW	HIGH	$6.76\times {10}^{-7}$	LOW
DNAJA2	LOW	LOW	$1.95\times {10}^{-10}$	LOW	X
EGLN3	HIGH	LOW	$1.38\times {10}^{-2}$	LOW	X
EP300	HIGH	LOW	$2.13\times {10}^{-5}$	LOW	X
EPHX2	LOW	HIGH	$2.13\times {10}^{-5}$	LOW
EPHX4	HIGH	LOW	$9.98\times {10}^{-2}$	HIGH
FASN	LOW	LOW	$1.10\times {10}^{-5}$	HIGH
GSTA4	LOW	HIGH	$3.12\times {10}^{-3}$	LOW
GSTM2	HIGH	HIGH	$4.70\times {10}^{-3}$	HIGH	X
GSTM3	LOW	HIGH	$1.13\times {10}^{-3}$	LOW
GSTM4	LOW	HIGH	$1.51\times {10}^{-1}$	LOW
GSTM5	HIGH	HIGH	$1.71\times {10}^{-1}$	LOW
HSP90AB1	LOW	LOW	$2.24\times {10}^{-4}$	LOW	X
HSPB8	HIGH	LOW	$7.81\times {10}^{-2}$	LOW
IVNS1ABP	HIGH	HIGH	$9.78\times {10}^{-7}$	LOW
KIF14	HIGH	LOW	$1.82\times {10}^{-6}$	HIGH
MAF	LOW	LOW	$7.43\times {10}^{-4}$	LOW	X
MGST1	LOW	HIGH	$3.39\times {10}^{-2}$	HIGH	X
MGST2	LOW	HIGH	$2.45\times {10}^{-6}$	LOW
MPHOSPH8	LOW	LOW	$2.50\times {10}^{-3}$	LOW	X
NCOA1	HIGH	HIGH	$2.69\times {10}^{-3}$	LOW
NCOA7	LOW	HIGH	$9.78\times {10}^{-7}$	LOW
NR2F1	LOW	HIGH	$2.69\times {10}^{-3}$	LOW
PARP1	LOW	LOW	$5.02\times {10}^{-2}$	HIGH
PPP1R12A	LOW	LOW	$3.24\times {10}^{-2}$	LOW	X
PSMC2	LOW	LOW	$1.09\times {10}^{-1}$	HIGH
PSMD3	LOW	LOW	$4.00\times {10}^{-5}$	HIGH
PTGES3	HIGH	LOW	$2.89\times {10}^{-4}$	LOW	X
PUS7	LOW	LOW	$8.77\times {10}^{-2}$	HIGH
RAF1	HIGH	LOW	$1.30\times {10}^{-1}$	HIGH
RB1	HIGH	LOW	$2.60\times {10}^{-6}$	LOW	X
RBX1	LOW	LOW	$2.50\times {10}^{-3}$	HIGH
RELA	LOW	LOW	$9.98\times {10}^{-2}$	HIGH
SF3B3	LOW	LOW	$7.43\times {10}^{-4}$	LOW	X
SMAD4	LOW	HIGH	$2.64\times {10}^{-5}$	LOW
SUMO2	HIGH	LOW	$1.57\times {10}^{-2}$	HIGH
SUV39H1	LOW	LOW	$2.50\times {10}^{-3}$	LOW	X
TERF2IP	LOW	HIGH	$1.71\times {10}^{-1}$	HIGH	X
TOMM34	LOW	HIGH	$7.06\times {10}^{-5}$	HIGH	X
TRIM52	HIGH	LOW	$9.77\times {10}^{-3}$	HIGH
UBLCP1	LOW	LOW	$2.08\times {10}^{-2}$	LOW	X
UGT1A1	HIGH	HIGH	$1.71\times {10}^{-1}$	HIGH
VIM	HIGH	LOW	$2.50\times {10}^{-3}$	HIGH