TABLE 1.
New trypsin cleavage sites are conserved in human and animal rotaviruses
| Rotavirus straina | P typeb | G type | Sequence at confirmed trypsin cleavage sitec
|
Sequence at putative trypsin cleavage site at amino acid 467 | |
|---|---|---|---|---|---|
| Amino acid 258 | Amino acid 582 | ||||
| Si/SA11 4F | 6[1] | 3 | DIVVSKTSLWK | RSASVRSVSST | YEIAGRFSLIS |
| Si/SA11 cl3 | 5B[2] | 3 | DIVISKTSLWK | RGSSIRSIGSS | YEIAGRFSLIS |
| Si/RRV | 5B[3] | 3 | DIVVSKTSLWK | RGASIRSVGSS | YEVAGRLSLIS |
| Hu/RV-5 | 1B[4] | 2 | DITISKTSLWK | RSASIRSNLST | YEMSGRFSLIS |
| Bo/UK | 7[5] | 6 | DIVVSKTSLWK | RSTSVRSIGST | YEVAGRFSFIS |
| Hu/1076 | 2A[6] | 2 | DIIISKTSLWK | RSSSIKSNISS | YEIAGRFSFIL |
| Po/OSU | 9[7] | 5 | DIVVSKTSLWK | RSSSIRSIGSS | YEISGRFSLIS |
| Po/YM | 9[7] | 11 | DIVVSKTSLWK | RSSSIRSIGSS | YEISGRLSLIS |
| Hu/Wa | 1A[8] | 1 | DIIVSKTSLWK | RNVSIRSNLSA | YEISGRFSLIY |
| Hu/K8 | 3[9] | 1 | DIVISKTSLWK | RLTSVRSVGTI | YEIAGRFSLIS |
| Hu/69M | 4[10] | 8 | DIIVSKTSLWK | RGSSIRSIGSS | YEVAGRFSLIS |
| Bo/B223 | 8[11] | 10 | DIIISKASLWK | RSSTLRSVNSA | YEAAGRFSLIL |
| Eq/H-2 | 4[12] | 3 | DIVISKTSLWK | RNSSIRSVSSS | YEIAGRFSLIS |
| Po/MDR-13 | [13] | 3/5 | DIVISKASLWK | RGSTIRSIGSS | YEINGRFSLIS |
| La/ALA | 11[14] | 3 | DIVVSKTSLWK | RSVSVRSIGGN | YEIAGRFSLIS |
| Ov/Lp14 | [15] | 10 | DIVISKASLWK | RNSSIRSIGST | YEIAGRFSLIS |
| Mu/EB | 10[16] | 3 | DIVVSKTSLWK | RSNTIRSISST | YELAGRFSLIS |
| Av/PO-13 | [17] | 7 | DIVISKTSLWK | RASSIRSNASV | YETAGRFSLIS |
| Eq/L338 | 12[18] | 13 | DILISKASLWK | RSSSIRSIGST | YEIAGRFSLIS |
| Po/PRV 4F | [19] | 3 | DIVISKASPWK | RNSSIRSNVSS | YEIAGRFSLIS |
| Mu/EHP | [20] | 3 | DVVISKASLWK | RSGSIRSISSN | YEVAGRFSLIS |
Species of origin for rotavirus strains are indicated by the following abbreviations: Hu, human; Si, simian; Mu, murine; Ca, canine; La, lapine; Eq, equine; Po, porcine; Bo, bovine; Av, avian; Ov, ovine.
Each P genotype is designated by the number in square brackets. Not all viruses in each P genotype have been characterized into a P serotype by neutralization assays.
Sequences were obtained with the following Genbank accession numbers: SA11 4F, X57319; SA11cl3, M23188; RRV, J03567; RV-5, M32559; UK, M22306; 1076, M88480; OSU, X13190; YM, M63231; Wa, M96825; K8, D90260; 69M, M60600; B223, D13394; H-2, L04638; MDR-13, L07886; ALA, U62149; Lp14, L11599; EB, U08419; PO-13, AB009632; L338, D13399; PRV 4F, L10359; EHP, U08424. The sites of cleavage are indicated in bold.