FIG. 4.

Synergistic effects of hantavirus infection and IFN-γ on RANTES and IP-10 gene expression by HMVEC-Ls. Measurements of SNV-specific induction of IP-10 and RANTES mRNA in HMVEC-Ls before (A) and after (C) treatment with IFN-γ (1,000 U/ml, 24 h) were determined by RPA at the indicated time points postinfection as described in the text and for Fig. 2. Quantitative densitometric measurements of IP-10, RANTES, and GAPDH gene expression for each of the treatment groups before (B) and after (D) treatment with IFN-γ (1,000 U/ml, 24 h) were determined as described in the text and for Fig. 2. Values for IP-10 and RANTES gene expression are the percentages of the GAPDH gene expressed in the same lane.