Table 3.

Symptoms’ prevalence in 2007 and in 2024.

	Group 1 (n = 71)	Group 2 (n = 61)	p
Constipation	18 (25.3%)	27 (44.2%)	0.027
Nausea	17 (23.9%)	13 (21.3%)	0.835
Vomiting	7 (9.8%)	12 (19.7%)	0.137
Diarrhea	19 (26.7%)	16 (26.2%)	0.556
Decreased appetite	27 (38%)	24 (39.3%)	1.000
Muscle cramps	44 (62%)	32 (52.4%)	0.293
Swelling in legs	15 (21.1%)	11 (18%)	0.826
Shortness of breath	28 (39.4)	26 (42.6%)	0.855
Dizziness	21 (29.5%)	15 (24.5%)	0.561
Restless legs	31 (43.6%)	17 (27.9%)	0.070
Numbness or tingling in feet	26 (36.6%)	19 (31.1%)	0.582
Feeling tired or lack of energy	63 (88.7%)	50 (82%)	0.324
Cough	13 (18.3%)	17 (27.9%)	0.215
Dry mouth	38 (53.5%)	39 (63.9%)	0.288
Bone or joint pain	46 (64.7%)	39 (63.9%)	1.000
Chest pain	8 (11.2%)	4 (6.5%)	0.382
Headache	15 (21.1%)	20 (32.8%)	0.166
Muscle soreness	41 (57.7%)	29 (47.5%)	0.294
Difficulty concentrating	29 (40.8%)	19 (31.1%)	0.279
Dry skin	50 (70.4%)	38 (62.3%)	1.000
Itching	44 (62%)	28 (45.9%)	0.080
Worrying	38 (53.5%)	42 (68.8%)	0.077
Feeling nervous	36 (50.7%)	34 (55.7%)	0.602
Trouble falling asleep	34 (47.8%)	26 (42.6%)	0.600
Trouble staying asleep	43 (60.5%)	29 (47.5%)	0.161
Feeling irritable	31 (43.6%)	34 (55.7%)	0.294
Feeling sad	41 (57.7%)	32 (52.4%)	0.600
Feeling anxious	37 (52.1%)	30 (49.2%)	0.861
Decreased interest in sex *	44 (64.7%)	46 (82.1%)	0.042
Difficulty in becoming sexually aroused *	42 (61.7%)	46 (82.1%)	0.016

* Three patients in 2007 and five patients in 2024 did not report data about these symptoms.