Table 4.
Symptoms’ severity in 2007 and in 2024.
| Group 1 (n = 71) |
Group 2 (n = 61) |
p | |
|---|---|---|---|
| Constipation | 1 ± 1 0 (0–4) |
1 ± 1 0 (0–4) |
0.017 |
| Nausea | 0 ± 1 0 (0–4) |
0 ± 1 0 (0–3) |
0.669 |
| Vomiting | 0 ± 1 0 (0–3) |
0 ± 1 0 (0–3) |
0.130 |
| Diarrhea | 0 ± 1 0 (0–3) |
0 ± 1 0 (0–2) |
0.873 |
| Decreased appetite | 1 ± 1 0 (0–4) |
1 ± 1 0 (0–4) |
0.844 |
| Muscle cramps | 1 ± 1 1 (0–4) |
1 ± 1 1 (0–3) |
0.085 |
| Swelling in legs | 0 ± 1 0 (0–4) |
0 ± 1 0 (0–3) |
0.661 |
| Shortness of breath | 1 ± 1 0 (0–4) |
1 ± 1 0 (0–3) |
0.678 |
| Dizziness | 1 ± 1 0 (0–4) |
0 ± 1 0 (0–3) |
0.488 |
| Restless legs | 1 ± 1 0 (0–4) |
1 ± 1 0 (0–4) |
0.039 |
| Numbness or tingling in feet | 1 ± 1 0 (0–4) |
1 ± 1 0 (0–3) |
0.566 |
| Feeling tired or lack of energy | 2 ± 1 2 (0–4) |
2 ± 1 2 (0–4) |
0.938 |
| Cough | 0 ± 1 0 (0–3) |
1 ± 1 0 (0–3) |
0.147 |
| Dry mouth | 1 ± 1 1 (0–4) |
1 ± 1 1 (0–4) |
0.289 |
| Bone or joint pain | 1 ± 1 1 (0–4) |
2 ± 2 1 (0–4) |
0.433 |
| Chest pain | 0 ± 0 0 (0–2) |
0 ± 0 0 (0–1) |
0.362 |
| Headache | 0 ± 1 0 (0–3) |
1 ± 1 0 (0–4) |
0.121 |
| Muscle soreness | 1 ± 1 1 (0–4) |
1 ± 1 0 (0–3) |
0.103 |
| Difficulty concentrating | 1 ± 1 0 (0–3) |
1 ± 1 0 (0–3) |
0.273 |
| Dry skin | 1 ± 1 1 (0–4) |
1 ± 1 1 (0–4) |
0.444 |
| Itching | 1 ± 1 1 (0–4) |
1 ± 1 0 (0–4) |
0.057 |
| Worrying | 1 ± 1 1 (0–4) |
1 ± 1 1 (0–4) |
0.352 |
| Feeling nervous | 1 ± 1 1 (0–4) |
1 ± 2 1 (0–12) |
0.563 |
| Trouble falling asleep | 1 ± 1 0 (0–4) |
1 ± 2 0 (0–13) |
0.974 |
| Trouble staying asleep | 1 ± 1 1 (0–4) |
1 ± 1 0 (0–4) |
0.967 |
| Feeling irritable | 1 ± 1 0 (0–4) |
1 ± 1 1 (0–4) |
0.337 |
| Feeling sad | 1 ± 1 1 (0–4) |
1 ± 1 1 (0–4) |
0.925 |
| Feeling anxious | 1 ± 1 1 (0–4) |
1 ± 1 0 (0–4) |
0.969 |
| Decreased interest in sex | 2 ± 2 2 (0–4) |
3 ± 2 3 (0–4) |
0.004 |
| Difficulty in becoming sexually aroused | 2 ± 2 2 (0–4) |
3 ± 2 3 (0–4) |
0.003 |
Data are presented as mean ± SD or median (95% CI).