Table 3.
Curcumin clinical studies for the management of microbial diseases.
| Disease | Number of Participants | Dose | Result | Reference |
|---|---|---|---|---|
| Chronic periodontitis | 23 | 1% curcumin solution, 0.2% chlorhexidine gluconate, and saline were used as irrigants | The curcumin group reduced bleeding scores more effectively than the control group | [125] |
| Oral plaque | 27 | LED lighting generating blue light with a curcumin concentration of 30 mg/L | Curcumin possesses the capability to disintegrate mouth plaque; salivary microbes can be reduced using the blue LED device that contains curcumin | [126] |
| Periodontitis | 25 | Locally applied 1% curcumin gel to treat periodontitis | A curcumin gel application dramatically lowered the periopathogen microbiological count; when used after scaling and root planing, curcumin gel effectively inhibits the growth of oral germs | [127] |
| Peptic ulcer | 30 | Curcumin (500 mg) along with piperine (5 mg) | Dyspepsia symptoms improved | [128] |
| Peptic ulcer | 21 | Clarithromycin (500 mg) + amoxicillin (1 g) + esomeperazole (20 mg) + curcumin (500 mg) | Reduction in pro-inflammatory IL-1B level; improved healing | [129] |
| Chronic gastritis | 24 | Omeprazole (20 mg) + amoxicillin (1 g) + metronidazole (800 mg) + curcumin (700 mg) | Reduction in oxidative DNA damage; improved clinical symptoms | [130] |
| COVID-19 | 70 mild to severe COVID-19 patients | Patients took a dietary supplement containing 2.5 milligrams of bioperine and 252 milligrams of curcumin | Reduced the length of hospital stays for patients with moderate to severe symptoms, showed early symptomatic recovery | [131] |
| COVID-19 | 30 mild to moderate COVID-19 patients | Patients in the Sinacurcumin® soft gel 40 mg group took two gels with meals: breakfast and dinner | Symptoms such as chills, cough, and smell/taste disturbances cleared up significantly faster than in the control group, with the exception of sore throat | [132] |
| COVID-19 | 115 | Dietary supplement: palmitoylethanolamideDietary supplement: curcumin | Curcumin supplementation reduced the proinflammatory response in patients recently diagnosed with COVID-19 | [76] |