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. 2024 Sep 2;14(9):1103. doi: 10.3390/life14091103

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Synaptic plasticity in Nrl transgenic retinas. (A) 1.5-month retinas of wild-type, Nrl^-/- (cone-only) and CrxpNrl (rod-only) mice stained by anti-PKCα (rod bipolar neurons, green) and anti-Goα (all ON bipolar neurons, red). (B) Retinas from 1.5-month-old Clm-GFP (type 9 cone bipolar neurons, green), Clm-GFP/Nrl^-/-, and Clm-GFP/CrxpNrl mice stained with anti-Ribeye (red). Abbreviations: WT, wild-type; Nrl, neural retina leucine zipper; CrxpNrl, Cone-rod homeobox promoter-driven Nrl; Clm, clomeleon; GFP, green fluorescent protein; PKCα, Protein Kinase C alpha; Goα, guanine nucleotide-binding protein alpha subunit; ONL, outer nuclear layer; OPL, outer plexiform layer; INL, inner nuclear layer. Scale bars, 10 μm in (A,B).