Table 1.
DAVID analysis of Rod upregulated NRL targets. This table displays relevant Gene Ontology (GO) terms and genes that could be associated with synapse development.
| GOterm | Go ID | Genes |
|---|---|---|
| myelin sheath | 0043209 | NSF, NAPB, HSP90AA1, ENO1B, ATP1A3, THY1, ENO1, COX6A1, NFASC, PKM, GNB1, GNB5, SLC25A12, ALDOA, SLC25A5 |
| synapse | 0045202 | RAB3A, NRN1, RPLP1, CABP4, CLSTN1, CAMK2A, ATP1A3, TULP1, YBX3, ZDHHC2, LY6C1, EPS8, GABRR2, GABRR1, SYNGR1, SV2B, TMEM108, RABAC1, SH3GL2, SNTA1, CACNG5, PTPRN2, WHRN, CARTPT, MYRIP, USH2A, CDH10, SPARCL1, RPS21, VAMP2, SNTB2 |
| neuron projection | 0043005 | HSP90AA1, PACRG, WHRN, CAMK2A, RTN4RL2, LSM4, EPS8, GABRR2, GABRR1, PCP4, NFASC, RIT2, SV2B, BBS7, STX3, VAMP2, CDK5R2, RGS6 |
| dendrite | 0030425 | GNAZ, RCVRN, KCNJ12, KCNIP2, CAMK2A, ZDHHC5, RTN4RL2, THY1, TRAK1, TXN2, SLC6A6, PEX5L, NFASC, GNB1, TMEM108, STX3 |
| Calcium ion binding | 0005509 | CRB1, SYT3, RCVRN, KCNIP2, CABP4, CLSTN1, GUCA1A, RHOT2, PCP4, EHD4, VSNL1, PITPNM1, CDH10, CDHR1, SPARCL1, PLCH2, SLC25A12, GAS6, NUCB2, SLC25A25, TGM3 |
| vesicle-mediated transport | 0016192 | NSF, NAPB, RAB4A, SYT3, TULP1, AP2A2, ARL4D, SPIRE2, STX3, VAMP2, HSPA1B, VTI1B, HSPA1A |
| ion transport | 0006811 | KCNG1, KCNJ5, KCNE2, KCNK9, KCNJ12, KCNIP2, SLC6A15, ATP1A3, SLC5A2, SLC4A5, GABRR2, GABRR1, NIPAL1, CNGA1, SCN4A |
| growth cone | 0030426 | EPS8, WHRN, ENO1B, RASGRF1, STX3, THY1, ENO1, CDK5R2 |
| calmodulin binding | 0005516 | PCP4, RIT2, CAMK2A, VAMP2, MYLK, SNTA1, SNTB2 |
| GABA-ergic synapse | 0030425 | SLC6A6, GABRR2, GABRR1, CDH10, CLSTN1, ZDHHC5 |
| postsynaptic membrane | 0045211 | SLC6A6, GABRR2, GABRR1, CLSTN1, CACNG5, SNTA1, SYNE1 |
| chemical synaptic transmission | 0007268 | GABRR2, GABRR1, SV2B, CLSTN1, CARTPT |
| extracellular matrix | 0031012 | ADAMTSL1, COL26A1, COL3A1, ADAMTS3, COL4A3, RTN4RL2, MMP9 |
| transmembrane transport | 005508 | KCNG1, SLC25A29, SV2B, CNGA1, SCN4A, SLC5A2, SLC25A5, SLC25A12, SLC25A25, SLC4A5 |
| cell adhesion | 0007155 | NFASC, PRPH2, CDHR1, CDH10, CLSTN1, ROM1, COL4A3, ADAM9, SPG7, THY1, CD34 |
| extracellular region | 0005576 | CRB1, CCDC126, CDNF, PRCD, CLSTN1, LOXL4, TULP1, PLA2G7, GLB1L2, CST3, ADAMTSL1, FTH1, NRTN, FAM3C, CD34, ST3GAL1, CTSB, CHGA, COL26A1, CARTPT, MMEL1, USH2A, MMP9, POMC, COL3A1, RBP3, QPCT, COL4A3, SPARCL1, GAS6, NUCB2, HSPA1A |
129 genes: ADAM9, ADAMTS3, ADAMTSL1, ALDOA, AP2A2, ARL4D, ATP1A3, BBS7, CABP4, CACNG5, CAMK2A, CARTPT, CCDC126, CD34, CDH10, CDHR1, CDK5R2, CDNF, CHGA, CLSTN1, CNGA1, COL26A1, COL3A1, COL4A3, COX6A1, CRB1, CST3, CTSB, EHD4, ENO1, ENO1B, EPS8, FAM3C, FTH1, GABRR1, GABRR2, GAS6, GLB1L2, GNAZ, GNB1, GNB5, GUCA1A, HSP90AA1, HSPA1A, HSPA1B, KCNE2, KCNG1, KCNIP2, KCNJ12, KCNJ5, KCNK9, LOXL4, LSM4, LY6C1, MMEL1, MMP9, MYLK, MYRIP, NAPB, NFASC, NIPAL1, NRN1, NRTN, NSF, NUCB2, PACRG, PCP4, PEX5L, PITPNM1, PKM, PLA2G7, PLCH2, POMC, PRCD, PRPH2, PTPRN2, QPCT, RAB3A, RAB4A, RABAC1, RASGRF1, RBP3, RCVRN, RGS6, RHOT2, RIT2, ROM1, RPLP1, RPS21, RTN4RL2, SCN4A, SH3GL2, SLC25A12, SLC25A25, SLC25A29, SLC25A5, SLC4A5, SLC5A2, SLC6A15, SLC6A6, SNTA1, SNTB2, SPARCL1, SPG7, SPIRE2, ST3GAL1, STX3, SV2B, SYNE1, SYNGR1, SYT3, TGM3, THY1, TMEM108, TULP1, TXN2, USH2A, VAMP2, VSNL1, VTI1B, WHRN, YBX3, ZDHHC2, ZDHHC5. SynGO analyses also provided genes underlined.