Table 3.
DAVID analysis of Rod upregulated and SCL down-regulated genes. This table displays relevant Gene Ontology (GO) terms and genes that could be associated with synapse development.
| GOterm | Go ID | Genes |
|---|---|---|
| synapse | 0045202 | SYNPR, RNF112, GRM5, CDH10, PDYN, SHISA9, CDH9, INSYN2A |
| cell-cell junction assembly | 0007043 | CDH10, NR1H4, CDH9 |
| neuronal dense core vesicle lumen | 0099013 | IGF1, PDYN |
| postsynaptic membrane | 0045211 | GRM5, GRM6, SHISA9, CDH9 |
| glutamatergic synapse | 0098978 | GRM5, CDH10, IGF1, SHISA9, CDH9 |
| postsynaptic density | 0014069 | RNF112, GRM5, SHISA9, INSYN2A |
| calcium-mediated signaling using intracellular calcium source | 0035584 | GRM5, VCAM1 |
| myotube differentiation | 0014902 | IGF1, ANKRD2 |
| response to zinc ion | 0010043 | VCAM1, ABCC8 |
| regulation of long-term neuronal synaptic plasticity | 0048169 | GRM5, AGT |
| dendrite | 0030425 | GRM6, GNB1, PDYN, CDH9 |
| extracellular region | 0005576 | TAFA4, VCAM1, FRZB, IGF1, PDYN, BMP7 |
19 genes: ABCC8, AGT, ANKRD2, BMP7, CDH9, CDH10, FRZB, GNB1, GRM5, GRM6, IGF1, INSYN2A, NR1H4, PDYN, RNF112, SHISA9, SYNPR, TAFA4, VCAM1. SynGO analyses also provided genes underlined. A total of 11 genes (Italic) showed the highest expression in either central nervous system (CNS) embryonic day18 (E18), cerebellum adult, or frontal lobe cortex compared to other tissues in mouse ENCODE transcriptome data.