Table 4.

Descriptive statistics for the dynamic individual features (measured over one year) of eyes classified as ETDRS 43–47, which improve and worsen within two years, revealing statistically significant differences (with p-values < 0.05) between the two groups. Additionally, descriptive statistics are provided for other features that were used to improve the characterization of the stages of NPDR and associated compensatory mechanisms. The n refers to the number of eyes.

	ETDRS			p-Value
	Overall (n = 12)	43–47_Improve (n = 10)	43–47_Worse (n = 2)
MAT 6 months (no. per 6 months)				0.03
Mean (SD)	7.43 (9.65)	3.75 (3.36)	25.8 (10.6)
Median [Min, Max]	4.2 [0, 33.3]	4.1 [0, 10.4]	25.8 [18.3, 33.3]
MAT 12 months (no. per 12 months)				0.028
Mean (SD)	3.88 (5.16)	2.08 (2.97)	12.9 (4.24)
Median [Min, Max]	1.5 [0, 15.9]	1 [0, 9.4]	12.9 [9.9, 15.9]
//_VD_InR_DCP (mm−1/6 months)				0.83
Mean (SD)	−0.943 (1.04)	−0.93 (0.978)	−1.01 (1.82)
Median [Min, Max]	−1.01 [−2.39, 0.287]	−1.01 [−2.39, 0.287]	−1.01 [−2.29, 0.28]
//_VD_InR_SCP (mm−1/6 months)				0.83
Mean (SD)	−0.216 (0.428)	−0.219 (0.47)	−0.202 (0.152)
Median [Min, Max]	−0.178 [−0.899, 0.399]	−0.178 [−0.899, 0.399]	−0.202 [−0.31, −0.0949]
//_PD_InR_DCP (u.a./6 months)				0.133
Mean (SD)	−0.0208 (0.0184)	−0.0175 (0.0182)	−0.0376 (0.00849)
Median [Min, Max]	−0.0228 [−0.0464, 0.00452]	−0.0189 [−0.0464, 0.00452]	−0.0376 [−0.0436, −0.0316]
//_PD_InR_SCP (u.a./6 months)				0.197
Mean (SD)	−0.0115 (0.011)	−0.00975 (0.0106)	−0.0203 (0.0114)
Median [Min, Max]	−0.0104 [−0.0286, 0.00659]	−0.00878 [−0.0286, 0.00659]	−0.0203 [−0.0283, −0.0122]

Notation: //—slope measured between the baseline and the 12-month follow-up; MAT—microaneurysm turnover; VD—skeletonized vessel density; PD—perfusion density; SCP—superficial capillary plexus; DCP—deep capillary plexus; InR—inner ring.