TABLE 2.

Transcatheter Mitral Valve Devices

Mechanism	Device	Manufacturer	Implant Method	Sheath Size	Device Details	Study Details	EFS	Pivotal	CE Mark	FDA
mTEER	MitraClip	Abbott Structural	TFV, TS	24-F	Recapitulates the surgical Alfieri stitch, creating a biorifice MV that reduces MR. 4 clip sizes.	COAPT (NCT01626079)		X	X	X
	Pascal	Edwards Lifesciences	TFV, TS	22-F	1 clip size. Central spacer reduces central MR.	CLASP IIF (NCT03706833)		X	X	X
	Dragonfly	Hangzhou Valgen	TFV, TS	24-F	4 clip sizes: 4- to 6-mm width, 9- to 12-mm length	NCT04528576	X
TMVR	Tendyne	Abbott Structural	TA	34-F	Valve seated in an inner frame, which rests within a conformable outer frame. Device is secured by an apical tether.	SUMMIT (NCT03433274)		X	X
	Intrepid	Medtronic	TA, TFV, TS	35-F	Dual construction with a conformable outer stent with flexible brim and a circular inner stent housing the valve	APOLLO (NCT03242642)		X
	Sapien M3	Edwards Lifesciences	TFV, TS	20-F	2-component device: valve implanted within a subannular dock	ENCIRCLE (NCT04153292)		X
	Evoque Eos	Edwards Lifesciences	TFV, TS	28-F	Bovine pericardial valve secured by subannular anchors	MISCEND (NCT02718001)	X
	AltaValve	4C Medical	TA	32-F	Valve secured within a supra-annular spherical cage	NCT03997305	X
	Clarity	Highlife Medical	TFV, TS	39-F	2-component device; valve implanted within a subannular ring	HighFLO (NCT04888247)	X
	Cephea	Abbott Structural	TFV, TS	38-F	Valve anchored by axial compression created by ventricular and atrial disks	NCT05061004	X
	Cardiovalve	Cardiovalve	TFV, TS	28-F	Low-profile design featuring 3 scalloped bovine pericardial leaflets	AHEAD (NCT03339115)	X
	Saturn	Innovheart	TA		Central valve component anchored in an annular ring	NCT04464876	X
	Innostay	Innovalve	TFV, TS	32-F	Circumferential arm design seals annulus using a rotational maneuver during deployment	TWIST-EFS (NCT04919980)	X
Annuloplasty	Carillon	Cardiac Dimensions	CS	9-F	Device with proximal and distal helical anchors that plicate mitral periannular tissue	EMPOWER (NCT03142152)		X	X
	ARTO	MVRx	CS	12-F	Anchors implanted in the lateral wall via the CS and the septum are bridged to reduce the MV minor axis dimensions.	MAVERICK (NCT03311295)	X
Other	NeoChord	NeoChord	TA (DS1000) TFV, TS (NeXuS)	28-F	Neochordae created using a device that features a helical papillary muscle anchor and a suture that grasps the MV leaflet.	ReChord (NCT02803957) (TA)		X	X (TA)
	Half Moon	Half Moon	TFV, TS	29-F	Improved native leaflet coaptation by filling the posterior aspect of the regurgitant orifice with an ePTFE-coated device implanted in a circular frame	NCT04343313	X

CE = Conformite Europeenne; CS = coronary sinus; EFS = early feasibility study; ePTFE = expanded polytetrafluoroethylene; FDA = Food and Drug Administration; mTEER = mitral transcatheter edge-to-edge repair; MV = mitral valve; TA = transapical; TFV = transfemoral vein; TMVR = transcatheter mitral valve replacement; TS = transseptal; other abbreviation as in Table 1.