Figure 10.

Working model of the transcriptional regulation of HSF5 during male meiosis. HSF5 functions as a transcription factor that binds to the promoters of meiosis‐related genes, including synapsis‐related genes (e.g., SYCP1, SYCP2 and SYCE3), the recombination‐related gene TEX15, crossover formation genes (e.g., HFM1, MLH3 and MSH5) and the MSCI gene MDC1, to maintain their expression; deficiency in HSF5 causes aberrant meiotic sex chromosome synapsis, recombination, crossover formation, and MSCI, which leads to spermatocyte apoptosis and meiotic arrest at the late pachytene stage. Dashed boxes indicate compromised function. Created with BioRender.com.