Table 2.
Cox regression model of patients with/without HPV for colorectal cancer.
| Adjusted HR | 95% CI | p | |
|---|---|---|---|
| HPV | 1.73 | 1.63–1.83 | <0.0001 |
| Sex | |||
| Male | 1.49 | 1.40–1.58 | <0.0001 |
| Female | Reference | ||
| Age | |||
| 0–19 years | 0.04 | 0.02–0.08 | <0.0001 |
| 20–39 years | Reference | ||
| 40–59 years | 6.81 | 6.00–7.72 | <0.0001 |
| 60–79 years | 21.26 | 18.67–24.20 | <0.0001 |
| 80+ years | 34.69 | 29.78–40.40 | <0.0001 |
| Urbanization | |||
| 1 (Highest level) | Reference | ||
| 2 (Very high level) | 0.94 | 0.86–1.02 | 0.1157 |
| 3 (High level) | 0.98 | 0.89–1.09 | 0.7578 |
| 4 (Moderately high level) | 0.92 | 0.83–1.03 | 0.17 |
| 5 (Moderate level) | 0.87 | 0.70–1.08 | 0.2077 |
| 6 (Low level) | 0.71 | 0.58–0.85 | 0.0003 |
| 7 (Lowest level) | 0.93 | 0.77–1.13 | 0.4672 |
| Area | |||
| Taipei | Reference | ||
| Northern | 0.95 | 0.85–1.06 | 0.3231 |
| Central | 1.03 | 0.94–1.13 | 0.5037 |
| Southern | 1.20 | 1.09–1.33 | 0.0004 |
| Kaohsiung-Pingtung | 1.03 | 0.93–1.13 | 0.6043 |
| Eastern | 0.98 | 0.78–1.22 | 0.833 |
| Insurance coverage | |||
| Public insurance | 0.96 | 0.85–1.08 | 0.4893 |
| Labor insurance | Reference | ||
| Agricultural, Irrigation, Fishery Associations | 1.09 | 0.99–1.20 | 0.0917 |
| Low-income | 1.19 | 0.85–1.67 | 0.3165 |
| Unemployment | 1.02 | 0.94–1.11 | 0.596 |
| Other | 0.97 | 0.75–1.26 | 0.8318 |
| Co-morbidity | |||
| Ischemic heart disease | 0.99 | 0.91–1.08 | 0.8113 |
| Hypertension | 1.22 | 1.13–1.31 | <0.0001 |
| Stroke | 1.06 | 0.95–1.18 | 0.3014 |
| Diabetes mellitus | 1.32 | 1.22–1.43 | <0.0001 |
| Abnormal liver function | 1.18 | 1.07–1.30 | 0.001 |
| Renal failure | 1.13 | 0.88–1.45 | 0.3416 |
| Gastrointestinal bleed | 1.20 | 0.95–1.52 | 0.1367 |
| Hyperlipidemia | 1.07 | 0.99–1.16 | 0.0921 |
| Chronic kidney diseases | 1.22 | 1.00–1.50 | 0.0508 |
| COPD | 1.09 | 0.97–1.23 | 0.1389 |
| Peptic ulcer | 0.99 | 0.91–1.07 | 0.7521 |
| Gout | 1.01 | 0.91–1.13 | 0.827 |
Adjustment for sex, age, urbanization, area, insurance coverage, and co-morbidity. HPV, Human Papillomavirus; COPD, Chronic Obstruction Pulmonary Disease.