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. 2024 Jul 1;11(33):2402152. doi: 10.1002/advs.202402152

Figure 4.

Figure 4

Higher percentages of loss in long‐range projections following hematoma in the mPFC. A) Schematic diagram illustrating the mPFC whole‐brain circuit connection. The distance from the mPFC is classified into three parts: short, medium, and long. Abbreviation. CLA: claustrum; BLA: basal lateral amygdala; THAL: thalamus; PAG: Gray matter around the aqueduct. B) Changes in fluorescence observed in corresponding brain regions in the Ctx, CLA, BLA, and mPFC at varying volumes of hematoma. Scale bar, 100 µm. C) Heat map of the injury percentage for the mPFC whole‐brain circuit connection with varying distances from anterior‐posterior (AP) under different hematoma volumes. D–F) Linear fitted trend of the injury percentage for the mPFC whole‐brain circuit connection at varying distances from AP under different hematoma volumes. A line with linear regression was fitted. (D) Blood 5 µL: R2 = 0.74, P < 0.0001, Y = 0.11*X – 0.080; (E) Blood 10 µL: R2 = 0.76, P < 0.0001, Y = 0.17*X – 0.21; (F) Blood 15 µL: R2 = 0.69, P < 0.0001, Y = 0.14*X – 0.06. In (A–C), each group, n = 3 mice.