Chronic stresses induce extensive behavioral and inflammatory factors responses in mice (n = 6/group). (a) Schematic representation of the experimental design. (b) Percentage of weight gain during SD on the last day. (c) Distance of motion in open arms. (d) The time spent in open arms in SD mice. (e) Percentage of weight gain during WAS on the last day. (f) Distance of motion in open arms. (g) The time spent in open arms in WAS mice. (h) Distance of motion in novel arm. (i) The time spent in novel arms. (j) Spontaneous alternation rate. ELISA analyses of (k) TNF-α, (l) IL-6, (m) MDA, and (n) IL-1β in SD mice. (o) Abdominal withdrawal reflex scores in response to CRD. (p) The numbers of fecal pellets found in containers during WAS on the last day. ELISA analyses of (q) TNF-α, (r) IL-6, (s) IL-1β, and (t) MDA in WAS mice. Statistics: * p < 0.05, ** p < 0.01, *** p < 0.001.