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. 2024 Aug 31;17(9):1156. doi: 10.3390/ph17091156

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Water solutions of (a) eugenol (E) and Soluplus^® (S)/Lutrol F 127 (L). The ratios from left to right are the following: E:S = 1:1; E:S = 1:2; E:L = 1:1; E:L = 1:1.33; and E:L = 1:2. Only in the case of E:L = 1:2 is no precipitate observed; (b) selected spray-dried solid powders (200 mg in 5 mL H₂O) with different amount of eugenol with respect to the mass of Soluplus^®: from left to right, 15% eugenol, 10% eugenol and 5% eugenol—no precipitate is formed. The solution’s turbidity is due to the high Soluplus^® concentration and the increased size of the Soluplus^® micelles due to the presence of eugenol.