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The model of PABPC1’s role in RSV infection. While the host PABPC1 is in a position to help the host control RSV genome synthesis, RSV induces tRF5-GluCTC to interfere with PABPC1 function. RSV infection induces cytosolic tRF5-GluCTC from its parent tRNA-GluCTC via angiogenin-mediated cleavage. The induced tRF5-GluCTC then binds to PABPC1, resulting in less PABPC1 being available to the RSV M protein, subsequently enhancing viral assembly.
