Table A3.
Ex vivo organ biodistribution (%ID/g) of [68Ga]Ga-DOTA-AeK in a dual-mice model of infection (E. coli or S. aureus) and inflammation at Day 3 and 5 post-inoculation.
| Post-Inoculation | E. coli | S. aureus | ||||
|---|---|---|---|---|---|---|
| Day 3 (n = 4) | Day 5 (n = 4) | * p-Value | Day 3 (n = 5) | Day 5 (n = 3) | * p-Value | |
| Brain | 0.1 ± 0.0 | 0.2 ± 0.2 | 0.344 | 0.1 ± 0.0 | 0.2 ± 0.0 | 0.030 |
| Thyroid | 1.0 ± 0.7 | 0.7 ± 0.3 | 0.497 | 0.9 ± 0.5 | 1.9 ± 0.3 | 0.020 |
| Heart | 0.8 ± 0.4 | 1.6 ± 1.3 | 0.299 | 1.2 ± 0.3 | 3.7 ± 0.5 | 0.000 |
| Lungs | 1.0 ± 0.1 | 2.0 ± 0.4 | 0.003 | 1.8 ± 0.5 | 3.7 ± 0.5 | 0.002 |
| Liver | 1.1 ± 0.2 | 1.2 ± 0.4 | 0.631 | 1.5 ± 0.5 | 3.6 ± 1.5 | 0.024 |
| Spleen | 0.7 ± 0.3 | 0.7 ± 0.1 | 0.986 | 1.4 ± 1.6 | 1.6 ± 0.6 | 0.801 |
| Pancreas | 0.6 ± 0.3 | 0.8 ± 0.4 | 0.450 | 0.7 ± 0.3 | 2.3 ± 0.2 | 0.000 |
| Stomach | 0.3 ± 0.1 | 1.3 ± 1.8 | 0.295 | 0.7 ± 0.5 | 1.1 ± 0.4 | 0.347 |
| Intestines | 0.4 ± 0.2 | 1.1 ± 1.2 | 0.356 | 1.2 ± 1.9 | 1.8 ± 0.8 | 0.653 |
| Kidneys | 3.8 ± 1.6 | 2.9 ± 0.7 | 0.374 | 5.6 ± 3.4 | 7.0 ± 0.1 | 0.512 |
| Adipose | 0.7 ± 0.1 | 0.8 ± 0.7 | 0.459 | 1.0 ± 0.4 | 1.9 ± 0.3 | 0.010 |
| Femur | 1.4 ± 1.0 | 0.9 ± 0.4 | 0.453 | 1.2 ± 1.3 | 2.0 ± 0.2 | 0.335 |
| Muscle | 0.7 ± 0.4 | 0.6 ± 0.2 | 0.632 | 0.4 ± 0.4 | 1.1 ± 0.5 | 0.041 |
| Inflammation | 0.9 ± 0.0 | 0.9 ± 0.1 | 0.987 | 1.1 ± 0.5 | 2.6 ± 0.6 | 0.010 |
| Infection | 0.4 ± 0.1 | 0.4 ± 0.0 | 0.398 | 0.8 ± 0.6 | 0.9 ± 0.3 | 0.781 |
| Inflammation/muscle | 2.0 ± 1.6 | 1.8 ± 0.8 | 0.492 | 7.1 ± 9.9 | 2.1 ± 0.3 | 0.064 |
| Infection/muscle | 0.8 ± 0.5 | 0.8 ± 0.3 | 0.771 | 3.0 ± 0.2 | 0.8 ± 0.1 | 0.559 |
* Unpaired t-tests were performed for comparison; p < 0.05 was considered statistically significant.