Table 2.

Demographic, anthropometric, plasmatic profile, sleep quality, and mood before and after supplementation.

LL1 + Silymarin
Sample size (M/F)	22 (7/15)
Age (years)	58.54 ± 5.65
Height (m)	1.62 ± 0.10
Anthropometrics
	T0		T180
	Mean ± SD		Mean ± SD		p
BMI (kg/m2)	28.9 ± 0.67		28.3 ± 0.76		0.0465
Neck (cm)	36.3 ± 0.70		35.7 ± 0.73		0.0049
Plasmatic profile
Total Cholesterol (mg/dL)	194 ± 7.81		208 ± 7.19		0.0255
HDL-C (mg/dL)	45.7 ± 2.3		51.8 ± 2.61		0.0002
IgM (mg/dL)	104 ± 10.4		107 ± 10.4		0.0106
Albumin (g/dL)	4.65 ± 0.043		4.93 ± 0.052		0.0001
Creatinine (mg/dL)	0.83 ± 0.36		0.90 ± 0.04		0.0007
TSH (mUI/L)	2.02 ± 0.243		2.72 ± 0.352		0.0479
Thyroxine (ng/dL)	0.981 ± 0.045		1.36 ± 0.043		0.0001
IL-8 (pg/mL)	0.859 ± 0.231		0.422 ± 0.156		0.0161
	T0		T180
	Mean ± SD	CI 95%	Mean ± SD	CI 95%	p
Pittsburgh Sleep Quality Index (PSQI)
PSQI Global score	6.39 ± 3.12	5.04–7.74	5.17 ± 2.77	3.97–6.37	0.0198
(C1) Sleep Quality	1.17 ± 0.65	0.89–1.46	0.83 ± 0.57	0.57–1.08	0.0078
(C2) Sleep Latency	1.09 ± 0.85	0.72–1.45	0.78 ± 0.16	0.44–1.13
(C3) Sleep Duration	1.17 ± 0.58	0.93–1.42	1.30 ± 0.87	0.93–1.68	-
(C4) Sleep Efficiency	0.43 ± 0.73	0.12–0.75	0.43 ± 0.89	0.05–0.82	-
(C5) Sleep Disturbance	1.13 ± 0.55	0.89–1.37	0.96 ± 0.47	0.75–1.16	-
(C6) Sleep Medication	0.26 ± 0.75	−0.06–0.59	0.13 ± 0.62	−0.14–0.40	-
(C7) Daytime Dysfunction	1.35 ± 1.43	0.73–1.97	0.68 ± 0.65	0.39–0.97	0.0042
Brunel Mood Scale (BRUMS)
BRUMS total score	20.14 ± 1.31	17.40–22.89	21.62 ± 1.46	18.56–24.68	-
Tension	3.90 ± 1.09	3.41–4.40	4.41 ± 1.71	3.65–5.17	-
Depression	2.38 ± 1.66	1.63–3.14	3.77 ± 3.24	2.34–5.21	-
Anger	3.19 ± 2.27	2.16–4.22	1.90 ± 1.61	1.17–2.64	0.0082
Confusion	3.90 ± 1.04	3.43–4.38	4.62 ± 1.47	3.95–5.29	0.0199
Vigor	3.48 ± 1.66	2.72–4.23	4.29 ± 1.55	3.58–4.99	0.0420
Fatigue	3.10 ± 1.34	2.49–3.70	3.24 ± 1.30	2.65–3.83	-

BMI: body mass index; HDL-C: high-density lipoproteins cholesterol; TSH: thyroid-stimulating hormone.