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Hierarchy of evidence for FA and 5-MTHF regarding neural tube defects (NTDs). A literature search was conducted in PubMed using the following search terms: ‘folic acid[title] AND neural tube defects[title] AND supplementation’; or ‘(5-MTHF[title] OR methyltetrahydrofolate[title]) AND neural tube defects[title] AND supplementation’. Created with BioRender.com.
