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. 2024 Aug 31;17(9):1154. doi: 10.3390/ph17091154

Table 2.

Five dose results of compounds 2c, 2e, 2f, 2g, 2h, 2i, 2p, and CA-4 in μM.

Cell Line Panel/Cell Line NAME 2c 2e 2f 2g 2h 2i 2p CA-4
GI50 LC50 TGI GI50 IC50 LC50 TGI GI50 IC50 LC50 TGI GI50 LC50 TGI GI50 IC50 LC50 TGI GI50 LC50 TGI GI50 IC50 LC50 TGI GI50 LC50 TGI
Leukemia CCRF-CEM 3.68 >100 >100 2.45 3.72 >100 7.94 2.88 3.98 >100 11.22 3.06 >100 61.5 2.14 3.39 >100 6.61 4.56 >100 >100 2.45 3.55 >100 8.71 0.10 89.95 5.43
HL-60(TB) 2.83 >100 32.2 2.24 4.27 >100 7.08 3.55 5.89 >100 38.02 1.94 >100 9.92 1.95 3.31 >100 5.75 3.05 >100 16.9 2.57 3.89 >100 11.22 0.03 59.02 0.06
K-562 3.25 >100 48.8 3.39 4.27 >100 >100 3.89 4.68 >100 >100 2.73 >100 >100 3.09 3.72 >100 >100 3.5 >100 >100 3.02 3.72 >100 >100 0.03 >100 2.09
MOLT-4 16.7 >100 64.3 2.82 4.27 >100 >100 14.45 24.55 >100 79.43 3.57 >100 36.6 3.47 5.01 >100 30.2 3.79 >100 >100 2.88 4.17 >100 22.91 0.10 78.34 3.72
RPMI-8226 2.85 >100 >100 2.04 3.72 >100 5.5 2.4 4.68 >100 8.32 2.29 >100 >100 2.04 3.72 >100 6.31 3.55 >100 >100 2.19 4.47 >100 9.12 0.15 96.61 6.50
SR 3.19 >100 >100 2.63 3.89 >100 >100 3.55 5.37 >100 56.23 2.83 >100 23.2 2.75 3.89 >100 >100 2.86 >100 >100 2.34 3.8 >100 16.22 0.11 >100 75.34
NSCLC A549/ATCC 12.4 57.7 26.8 4.79 7.41 >100 47.86 10.72 16.22 52.48 23.99 11.7 55.3 25.4 3.24 4.47 54.95 12.02 17 69 34.2 3.55 5.01 44.67 13.8 0.07 96.38 76.56
EKVX 12.8 64.6 28.7 10.47 23.99 95.5 31.62 12.88 23.99 52.48 26.3 10.6 51 23.3 5.75 15.14 46.77 19.5 16.4 58.1 30.9 4.07 10.96 >100 22.91 0.36 >100 82.04
HOP-62 3.83 48.7 16.2 2.57 4.68 74.13 6.31 5.37 12.02 72.44 22.91 3.94 61.2 14 3.98 6.76 40.74 12.3 6.43 67.7 23.2 3.16 5.37 >100 16.22 0.18 89.13 2.53
HOP-92 3.35 56 15.8 3.55 79.43 >100 30.9 11.48 30.2 63.1 26.92 6.44 58.8 22.5 3.89 22.39 44.67 16.6 12.2 64.4 28 2.95 44.67 >100 19.95 0.22 >100 36.31
NCI-H226 5.27 >100 27.6 4.37 29.51 >100 38.9 13.8 36.31 >100 38.02 4.13 >100 25.4 11.22 33.11 >100 38.02 15.6 >100 42.1 3.63 32.36 >100 36.31 0.67 96.16 48.98
NCI-H23 10.6 49.9 23 2.09 3.63 12.88 4.68 14.79 26.92 58.88 29.51 8.23 48 21.3 5.37 10 45.71 18.2 12.2 52.6 25.3 2.95 5.25 44.67 10.47 0.02 96.16 0.40
NCI-H322M 4.1 44.8 17.9 6.03 16.22 85.11 26.3 10.23 19.95 51.29 22.91 3.76 41.3 15.2 8.71 17.38 50.12 21.88 11 54.6 24.5 4.57 14.13 51.29 18.62 0.07 >100 74.82
NCI-H460 15.2 83.3 35.6 2.75 3.55 45.71 7.59 12.02 19.05 69.18 28.84 14.3 80.9 34.1 3.63 4.27 54.95 13.8 15.9 72.5 34 2.14 3.31 44.67 5.62 0.03 >100 66.83
NCI-H522 8.63 46.8 21.2 4.57 11.48 45.71 17.38 11.75 22.39 52.48 25.12 3.37 41.2 14.3 5.01 11.75 46.77 17.78 9.37 51.5 22.5 3.16 7.59 40.74 12.3 0.03 88.51 3.46
Colon Cancer COLO 205 15.4 80.4 35.2 3.55 5.25 51.29 14.45 19.05 33.88 74.13 38.02 13.9 80 33.3 5.75 8.71 51.29 19.05 15.9 >100 41.1 16.22 28.84 70.79 33.88 2.49 >100 43.25
HCC-2998 3.46 36.5 13.2 2.57 4.37 28.18 7.76 ND ND ND ND 2.72 31.6 9.62 2 3.63 11.75 4.57 9.37 47 21.5 5.13 11.75 44.67 17.38 0.05 26.85 1.22
HCT-116 3.99 42.5 15.2 1.82 2.95 7.41 3.63 6.61 7.94 74.13 24.55 3.82 40.9 13.1 2.88 3.31 >100 >100 2.78 44.3 7.89 3.16 3.63 69.18 14.45 0.03 >100 0.22
HCT-15 3.27 43.7 14.2 2.09 3.55 46.77 5.89 4.07 5.37 48.98 16.6 2.66 36.4 10 2.14 3.47 31.62 7.76 2.46 33.7 7.86 3.24 4.17 74.13 15.49 0.03 >100 9.51
HT29 10.6 52.4 23.6 2.24 3.55 12.59 4.9 6.76 9.55 53.7 20.89 5.09 57.8 19.3 5.5 7.24 60.26 19.95 10.7 68.7 27.1 3.47 4.57 >100 13.49 0.66 38.73 5.51
KM12 4.28 41 15.4 1.95 3.39 7.76 3.89 4.17 8.13 45.71 16.6 3.27 35.9 11 3.63 5.37 42.66 13.18 3.8 40 13.6 3.24 6.46 42.66 13.8 0.05 91.41 0.76
SW-620 3.37 49.3 15 1.91 3.16 7.59 3.8 3.09 4.37 38.9 11.22 2.82 41.6 11.7 3.39 4.07 45.71 10.96 3.59 44.2 13.9 2.57 3.72 46.77 9.77 0.03 >100 86.30
CNS Cancer SF-268 13 63.1 28.7 3.72 7.59 97.72 16.98 12.02 24.55 64.57 28.18 13.5 64.2 29.5 10.47 19.05 57.54 24.55 15.6 67.3 32.4 2.63 6.46 54.95 11.22 0.13 91.62 49.66
SF-295 12.5 52.9 25.7 4.37 11.48 43.65 16.98 15.85 28.84 54.95 29.51 12.7 52.7 25.8 3.63 8.71 39.81 14.79 16.1 56.5 30.2 5.5 14.45 66.07 21.38 0.07 >100 1.28
SF-539 2.94 35.5 10.8 2 3.63 8.32 4.07 6.92 16.22 47.86 20.42 2 12.8 4.67 2.19 3.98 12.88 4.9 2.31 27.2 7.02 2.19 4.47 20.89 5.5 0.04 86.90 0.20
SNB-19 4.87 43.1 17.8 7.76 16.98 48.98 21.38 12.02 22.39 50.12 24.55 3.47 37.7 13.4 4.9 11.75 41.69 16.98 5.42 43.2 18.3 5.01 13.18 43.65 17.78 0.04 >100 15.85
SNB-75 ND ND ND 1.66 3.8 7.76 3.63 2.19 8.51 28.84 6.76 ND ND ND 2.29 8.51 27.54 7.41 ND ND ND 2.19 7.59 28.84 6.17 0.83 82.41 24.72
U251 3.63 41.9 15.1 1.91 3.31 7.24 3.72 3.39 4.79 40.74 13.18 2.87 39.7 11.7 1.74 3.09 5.89 3.24 4.1 53 17 3.02 4.17 43.65 12.02 0.04 98.86 13.21
Melanoma LOX IMVI 3.26 36.6 12.7 1.66 2.88 5.75 3.09 3.39 4.47 38.02 12.02 2.8 33.7 10.2 1.58 2.75 6.03 3.09 1.85 8.91 4.06 3.24 4.47 38.9 12.02 0.01 >100 12.74
MALME-3M 12.4 60.9 27.5 2.24 5.13 50.12 5.75 14.45 30.9 75.86 33.11 12.5 67.2 29 12.3 24.55 54.95 26.3 13.7 70.8 31.1 5.75 17.78 54.95 20.42 0.44 >100 70.31
M14 6.97 56.7 22.2 2.88 4.17 >100 9.55 14.13 24.55 72.44 32.36 9.02 54.4 22.9 7.08 11.75 83.18 25.7 12.2 66.3 28.4 3.24 5.13 72.44 13.18 0.14 88.31 0.24
MDA-MB-435 4.24 48.7 17.5 2.09 3.55 16.98 5.01 5.5 10.96 48.98 19.05 4.12 45.1 16.7 4.57 7.41 44.67 16.98 7.39 50.9 21.1 2.57 4.47 >100 10.47 0.03 95.06 0.08
SK-MEL-2 11.6 50.1 24.1 10.47 29.51 70.79 27.54 13.8 27.54 56.23 28.18 5.87 47.9 19.5 12.59 26.92 53.7 26.3 13.6 62 29 3.09 10.96 42.66 11.48 8.20 >100 60.53
SK-MEL-28 11.8 51.4 24.7 2.14 4.07 13.49 4.9 14.45 26.3 53.7 28.18 11.9 50.2 24.5 5.5 13.18 44.67 18.2 13.7 52.5 26.8 4.07 9.12 57.54 17.38 3.16 90.78 82.41
SK-MEL-5 6.77 44.2 19.5 4.79 9.12 41.69 16.98 11.22 20.42 48.98 23.44 5.82 43 18.4 13.18 22.91 51.29 26.3 12 49.7 24.4 1.58 3.31 10 3.98 0.01 94.19 53.70
UACC-257 12.6 56.6 26.7 3.63 9.77 63.1 14.79 13.8 26.92 56.23 27.54 11.3 51.9 24.2 3.39 10 38.02 13.49 15.1 61.4 30.4 5.13 18.62 75.86 21.88 4.95 1.97 0.01
UACC-62 5.3 45.7 19.3 2.34 4.17 34.67 8.71 9.77 16.98 48.98 22.39 5.17 44.2 18.6 3.55 7.94 41.69 15.85 10.5 48.1 22.4 2.82 5.37 42.66 12.3 0.01 >100 80.54
Ovarian Cancer IGROV1 4.93 62.3 19.7 2.45 4.17 >100 6.46 13.18 25.7 93.33 34.67 3.29 53.4 11.9 3.02 4.9 47.86 12.3 4.43 50.8 14.9 3.31 5.75 >100 13.8 0.06 >100 63.53
OVCAR-3 2.42 24.5 6.81 2.29 4.17 22.91 6.03 2.82 6.46 33.11 10.72 1.88 9.7 4.27 2.4 4.37 23.99 6.46 2.22 16.6 5.28 2.45 5.25 25.7 6.92 0.04 93.54 61.66
OVCAR-4 6.03 44.7 19.6 4.47 12.88 >100 41.69 13.8 25.12 54.95 27.54 10.7 48.5 22.8 10.96 20.42 51.29 23.99 14.9 53.8 28.3 2.82 6.61 51.29 12.59 0.26 20.23 0.16
OVCAR-5 15.6 57.7 30 5.25 15.49 57.54 19.95 17.78 32.36 60.26 33.11 15.4 57.3 29.7 3.63 9.12 38.9 13.8 17.8 58.2 32.2 3.8 12.3 43.65 15.14 0.18 >100 83.18
OVCAR-8 3.99 50.9 16.2 2.69 3.89 >100 7.59 8.51 14.45 54.95 22.91 2.86 37.1 8.77 3.31 4.57 38.02 11.75 7.73 65.2 23.9 2.14 3.55 45.71 5.5 0.03 90.78 78.52
NCI/ADR-RES 5.92 85 24.9 2.88 5.01 >100 >100 3.72 7.08 77.62 17.38 6.04 73.4 23.4 2.51 4.27 >100 5.75 14.9 82.8 35.2 2.4 4.37 >100 7.41 0.06 90.36 39.17
SK-OV-3 11 61.8 26.1 17.38 51.29 >100 >100 15.85 30.2 66.07 32.36 13.8 74.9 32.2 5.89 15.14 45.71 18.62 18.6 76.9 37.8 7.41 46.77 >100 >100 28.44 89.54 0.36
Renal Cancer 786-0 4.59 47.1 17.6 2.51 4.07 37.15 6.31 4.68 7.76 58.88 20.42 3.33 41.8 13.3 3.98 6.31 50.12 15.85 3.99 54 17.6 4.57 6.61 97.72 20.89 0.02 >100 >100
A498 13.6 52.6 26.8 19.5 47.86 91.2 42.66 15.85 30.9 56.23 29.51 13.5 51.8 26.5 14.79 29.51 54.95 28.18 15.5 55.3 29.3 11.48 43.65 >100 34.67 0.05 >100 25.47
ACHN 7.02 44.3 19.6 2.29 3.72 21.38 6.03 13.8 23.99 51.29 26.92 7.67 45.4 20.3 4.07 6.17 38.9 14.79 11.3 48.4 23.3 3.89 6.46 54.95 16.6 0.01 >100 0.72
CAKI-1 6.89 45.4 20.2 4.68 15.49 69.18 20.89 4.47 8.71 43.65 17.38 10 47.2 21.8 10.47 20.42 51.29 22.91 13.9 52.7 27.1 2.57 4.68 45.71 13.18 0.04 97.05 8.22
RXF 393 3.02 37.2 13 1.91 5.13 10 4.37 5.89 23.99 48.98 19.95 2.58 33 9.43 10.23 24.55 47.86 22.39 4.88 44.8 18.6 2.51 11.22 30.9 7.08 0.89 >100 13.87
SN12C 3.95 46.7 17 2 3.55 8.91 4.27 4.9 10.72 43.65 18.2 3.15 36.8 13.1 2.69 4.37 33.11 10.23 6.06 44.7 19.3 2.29 3.89 46.77 9.55 0.01 91.62 82.04
TK-10 12.5 50.7 25.2 19.5 45.71 >100 47.86 15.14 28.18 54.95 28.84 3.04 35.2 11.8 11.22 22.91 50.12 23.44 12.4 51.3 25.3 5.01 16.22 47.86 17.78 0.57 >100 11.51
UO-31 2.88 41.2 15.7 1.55 2.88 6.03 3.09 4.07 11.22 47.86 18.2 2.46 39.7 13.5 3.89 10.72 43.65 16.98 4.86 46.3 18.8 3.02 7.76 46.77 15.49 0.19 >100 4.16
PC PC-3 5.82 >100 29.7 2.88 4.9 >100 13.8 5.37 9.77 81.28 23.44 4.68 >100 26 4.07 8.13 56.23 17.78 10.3 >100 37.3 5.01 8.91 >100 41.69 0.03 >100 51.40
DU-145 4.32 39.9 15.7 3.24 4.79 42.66 11.48 4.9 8.91 42.66 17.38 3.52 35.3 12 2.4 3.89 23.44 6.17 3.41 34.5 11 3.24 5.75 69.18 15.49 0.01 >100 78.89
Breast Cancer MCF7 2.65 37 11.4 3.31 8.13 37.15 12.3 3.16 4.68 43.65 13.18 2.57 38.7 10.6 2.75 6.31 38.02 9.77 2.67 51.3 11.7 3.02 4.27 45.71 10.72 0.04 >100 >100
MDA-MB-231/ATCC 15.7 66.1 32.2 2.45 6.17 39.81 6.92 16.22 30.9 61.66 31.62 10.9 50.9 23.5 5.25 16.22 44.67 17.78 12 51.5 24.8 3.24 10 >100 13.18 0.01 91.62 73.62
HS 578T 13.2 >100 40.2 3.09 >100 >100 85.11 21.38 >100 >100 77.62 10.4 >100 33 17.38 67.61 >100 52.48 13 80.9 32.4 2.88 >100 >100 39.81 0.15 >100 0.22
BT-549 2.34 33.1 8.27 2.24 5.89 28.18 6.17 5.75 20.89 57.54 20.42 2.6 30.6 7.28 3.8 13.49 43.65 14.79 5.04 48.5 19.3 2.95 11.75 50.12 10.72 0.01 99.54 8.09
T-47D 3.94 >100 28.8 3.39 7.94 >100 20.89 3.47 14.13 81.28 19.05 2.77 61.7 11.8 2 4.9 66.07 7.08 4.96 >100 25.7 2.19 7.24 >100 13.18 47.97 >100 2.04
MDA-MB-468 1.93 25.3 6.46 3.8 12.59 46.77 15.85 2.51 12.02 30.2 8.32 1.79 27.2 6.77 2.95 7.76 40.74 10.72 2.2 31.4 8 1.55 5.75 17.78 4.47 ND ND ND

ND: not determined.