Table 14.

Thermal- and ion-sensitive in situ gel systems for intranasal delivery.

Type of In Situ Gel	Reacting Agent	Refs.
Thermosensitive systems	Pluronic® F-127	[32,33,129,133]
	Poloxamer 407	[36,82,91]
	Chitosan derivatives	[92,131,134,144]
Ion-sensitive systems	Xanthan gum	[61,175]
	Gellan gum	[63,87,94,112,135,137]
	Carbopol®, HPMC	[58,101,126]