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. 2024 Sep 18;17(9):1228. doi: 10.3390/ph17091228

Table 4.

Summary of PET parameters. *: reached significance, X: did not reach significance, &: did not stay significant after Bonferroni multiple-test correction, NA: not available. TBRmax: Lmax/B, SUVmax/BG, LNR, TNR, LBRmax, T/Wm, TBRmax(20–40min), Tmax/B, maximum FET uptake, Tumax/BG; TBR3SD: Lmean/B, mean FET uptake; TBR25mm2: TBR, FET ratio; TBR10mm: TBRmean; TBR16mm: TBRmean, TBRmax; TBR70%: SUV70/BG; TBR80%: SUV80/BG; TBR: UR, FET lesion/brain ratio, FET uptake, tumor/brain tissue ratio, TBRmean, TBRmax; TAC: kinetic pattern, curve pattern; TTP: Tpeak; BTV: volume, MTV, Vol, Tvol 1.6; radiomic features: textural parameters.

Indication Number of Studies Grade Parameters Threshold Sensitivity Specificity AUC Accuracy Significance
Diagnosis
1 LGG and HGG Visual grading system - - - - - NA
1 LGG and HGG TBRmax - - - NA
1 LGG and HGG TBR25mm2 1.6 92% 81% - *
1 LGG and HGG TBR3SD - - - NA
1 LGG and HGG TBR 1.6 88% 88% - *
1 LGG and HGG 18F-FETn uptake 1.4 x background 76% 80% 0.89 78% *
Grading (LGG vs. HGG)
1 LGG and HGG FET uptake Reduced vs. normal vs. increased - - NA
1 LGG and HGG FET uptake pattern Inhomogeneous vs. diffuse vs. focal - - X
1 LGG and HGG Early SUV 2.32 73% 71% 72% *
1 LGG and HGG Middle SUV - - - - - X
1 LGG and HGG Late SUV - - - - - X
1 LGG and HGG e-m Ratio 0.93 93% 94% 94% *
1 LGG and HGG e-l Ratio 0.95 87% 88% 87% *
1 LGG and HGG SoD 0.5 93% 82% 87% *
1 LGG and HGG SUVmax - - - *
Grade 2/3 vs. Grade 4 1 LGG and HGG SUVsd 0.45 67% 87% 0.816 83% *
Grade 2/3 vs. Grade 4 1 LGG and HGG SUVmax/BG - - - *
2 LGG and HGG SUVmean/BG - - - X
Grade 2 vs. 3 LGG and HGG - - - X
Grade 2 vs. 3 1 LGG and HGG SUVtotal/BG - - - X
1 LGG and HGG SUV90 10–60 min 0.2 94% 100% 0.969 *
1 LGG and HGG SUV90 15–60 min −0.41 94% 100% 0.965 *
1 LGG and HGG TBRmax(0–10min) 2.8 76% 79% 76% *
1 LGG and HGG TBRmax(5–15min) 2.7 78% 76% 77% *
1 LGG and HGG TBRmax(5–20min) 2.6 80% 74% 76% *
1 LGG and HGG TBRmax(10–30min) 2.5 75% 75% 74% *
7 LGG and HGG TBRmax 2.58 71% 85% 0.798 *
LGG and HGG 2.62 82% 68% 0.83 78% *
Grade 2/3 vs. Grade 4 LGG and HGG 2.67 92% 61% 0.824 67% *
LGG and HGG 2.7 67% 78% 70% *
LGG and HGG - - - *
LGG and HGG - - - X
Grade 2 vs. 3 LGG and HGG - - - X
Grade 2/3 vs. Grade 4 1 LGG and HGG TBRpeak 2.35 92% 61% 0.832 67% *
2 LGG and HGG TBRmean 2 83% 58% 0.65 75% X
Grade 2/3 vs. Grade 4 LGG and HGG 2.31 58% 93% 0.791 86% *
1 LGG and HGG ∆TBRmean 20–40 min/70–90 min −8% 83% 75% 0.85 81% *
1 LGG and HGG TBR16mm 1.69 82% 68% 0.8 78% *
Grade 3 vs. 4 3 HGG TBR 1.68 - - 0.644 *
Grade 3 vs. 4 HGG 2.74 - - 0.614 X
LGG and HGG 3 - - *
4 LGG and HGG TTP 25 min 87% 100% 94% *
LGG and HGG 30 min 54% 91% 0.78 65% *
LGG and HGG 35 min 58% 92% 0.76 69% *
Grade 2/3 vs. Grade 4 LGG and HGG - - - - X
1 LGG and HGG Slope −0.03 SUV/h 64% 91% 0.78 72% *
7 LGG and HGG TAC II/III 88% 75% 83% *
LGG and HGG I/II vs. III 73% 100% 87% NA
LGG and HGG Decreasing 90% 66% 80% NA
Grade 2 vs. 3 LGG and HGG 88% 63% NA
LGG and HGG Increasing vs. Decreasing 95% 72% NA
LGG and HGG 96% 94% *
Grade 2/3 vs. Grade 4 LGG and HGG LGG-like vs. mixed vs. HGG-like - - - NA
Grade 2/3 vs. Grade 4 1 LGG and HGG COV 27.21 58% 91% 0.808 84% *
Grade 2/3 vs. Grade 4 1 LGG and HGG HI 1.77 67% 87% 0.826 83% *
Grade 3 vs. 4 4 HGG BTV 19.7 - - 0.71 *
Grade 2/3 vs. Grade 4 LGG and HGG 20.13 75% 80% 0.801 79% *
LGG and HGG - - - X
Grade 2 vs. 3 LGG and HGG - - - X
Grade 3 vs. 4 2 HGG TLU 46.2 - - 0.704 *
Grade 2/3 vs. Grade 4 LGG and HGG 50.93 75% 83% 0.841 81% *
Grade 2/3 vs. Grade 4 1 LGG and HGG Relative K1 - 85% 60% 0.766 *
Grade 2/3 vs. Grade 4 1 LGG and HGG Relative K2 - - - - X
Grade 2/3 vs. Grade 4 1 LGG and HGG Relative K3 - - - - X
Grade 2/3 vs. Grade 4 1 LGG and HGG Relative FD - 67% 78% 0.716 *
Grade 2/3 vs. Grade 4 1 LGG and HGG TBRmax + SUVsd + TBRmean - 75% 85% 0.850 83% *
Grade 2/3 vs. Grade 4 1 LGG and HGG HI + SUVsd + MTV - 75% 83% 0.848 81% *
Grade 2/3 vs. Grade 4 1 LGG and HGG HI + SUVsd + TLU - 75% 84% 0.848 81% *
Grade 2/3 vs. Grade 4 1 LGG and HGG SUVmax/BG + TTP - - - 0.745 *
Grade 2/3 vs. Grade 4 1 LGG and HGG SUVmax/BG + TTP + relative K1 + relative FD - - - 0.799 *
1 LGG and HGG Logistic regression using early SUV + SoD 50% 93% 100% 97% X
Radiomic features: *
Grade 3 vs. 4 1 HGG  Coarseness 0.607 - - 0.757 *
Grade 3 vs. 4 1 HGG  Contrast 0.203 - - 0.775 *
Grade 3 vs. 4 1 HGG  Busyness 1.12 - - 0.737 *
Grade 3 vs. 4 1 HGG  Complexity 0.069 - - 0.633 *
Grade 3 vs. 4 1 HGG  Combined 2.05 - - 0.830 *
IDH status determination
2 LGG and HGG SUVsd 0.11 47% 57% 0.710 66% *
LGG and HGG 0.23 - - - - *
5 LGG and HGG TBRmax 2.07 8% 100% 0.59 71% X
LGG and HGG 2.21 48% 87% 0.658 72% *
LGG - - - - - X
LGG and HGG - - - - - X
LGG and HGG - - - - - *
2 LGG and HGG TBRpeak 2.15 57% 73% 0.638 67% X
LGG and HGG - - - - - X
5 LGG and HGG TBRmean 1.68 12% 100% 0.66 73% *
LGG and HGG 1.84 62% 68% 0.633 66% X
LGG and HGG 1.85 44% 92% 0.73 69% *
LGG and HGG - - - - - X
LGG and HGG - - - - - *
1 LGG and HGG TBR16mm 2.15 56% 77% 0.68 67% *
3 LGG TBR 1.3 89% 36% - - NA
LGG 1.6 71% 53% - - NA
LGG 2.0 57% 68% - - NA
3 LGG and HGG TTP 25 min 86% 60% 0.75 72% *
LGG and HGG 45 min 27% 93% 0.75 73% *
LGG and HGG - - - - - *
3 LGG and HGG Slope −0.26 SUV/h 81% 60% 0.75 70% *
LGG and HGG 0.30 SUV/h 58% 90% 0.79 80% *
LGG and HGG - - - - - *
1 LGG and HGG TAC centroid #1 vs. centroid #3 - - - - *
1 LGG and HGG COV 8.85 52% 76% 0.65 67% *
1 LGG and HGG HI 1.26 48% 87% 0.676 72% *
2 LGG and HGG BTV 19.48 90% 46% 0.66 62% *
LGG and HGG - - - - - X
2 LGG and HGG TLU 28.95 81% 57% 0.698 66% *
LGG and HGG - - - - - X
1 LGG and HGG TBRmean + TBR16mm 1.85 and 2.15 44% 91% - 69% *
1 LGG and HGG TTP + Slope 25 min and −0.26 SUV/h 77% 70% - 73% *
1 LGG and HGG TBRmean + TTP 1.85 and 25 min 40% 96% - 69% *
1 LGG and HGG TBR16mm + TTP 2.15 and 25 min 51% 94% - 73% *
1 LGG and HGG TBRmean + Slope 1.85 and −0.26 SUV/h 40% 94% - 68% *
1 LGG and HGG TBR16mm + Slope 2.15 and −0.26 SUV/h 47% 91% - 70% *
1 LGG and HGG TBRmax + SUVsd + TBRmean - 76% 84% 0.821 81% *
1 LGG and HGG HI + SUVsd + MTV - 86% 81% 0.804 83% *
1 LGG and HGG HI + SUVsd + TLU - 76% 84% 0.799 81% *
1 LGG and HGG Midline involvement Yes vs. no - - - - *
1 LGG and HGG Simple predictive model - 85% 71% 0.786 76% *
1 LGG and HGG PET-Radiomics model - 80% 74% 0.812 76% *
1 LGG and HGG Slope + Radiomic feature SZHGE - 54% 93% - 81% *
Radiomic features: *
1 LGG and HGG SkewnessH - 31% 90% 0.53 71% *
1 LGG and HGG LRHGE - 8% 100% 0.52 71% *
Prediction of oligodendroglial components
1 LGG and HGG SUVmean/BG 2.1 61% 59% *
1 LGG and HGG SUVtotal/BG 6.9 75% 66% *
2 LGG and HGG TBRmax 2.6 70% 72% *
LGG - - - *
3 LGG TBR 1.3 100% 23% NA
LGG 1.6 93% 48% NA
LGG 2 86% 65% NA
1 LGG and HGG BTV 4 mL 71% 69% *
Guided resection/biopsy
1 HGG BTV 1 cm3 *
1 LGG and HGG TBR25mm2 1.6 - - *
3 LGG TBR 1.6 54% 12% *
HGG 88% 46% *
LGG and HGG - - - 0.76 *
Detection of residual tumor
1 HGG TBR 1.6 - - *
1 LGG and HGG Visual uptake >Background - - *
Guided radiotherapy
7 HGG SUVmax 30% - - NA
HGG 40% - - NA
HGG 50% - - NA
HGG 60% - - NA
HGG 70% - - NA
HGG 80% - - NA
HGG 90% - - NA
1 HGG TBRmax 1.6 - - NA
5 HGG TBR 1.6 - - NA
HGG - - NA
HGG - - NA
HGG - - NA
HGG - - NA
Detection of malignant transformation in LGG
3 LGG TBRmax ∆ + 33% 72% 89% 0.87 78% *
LGG and HGG 2.46 82% 89% 0.92 85% *
LGG - 57% 41% 0.476 X
1 LGG TBRmean ∆ + 13% 72% 78% 0.8 74% *
2 LGG TTP ∆-6 min 72% 89% 0.78 78% *
LGG 25 min 57% 47% 0.511 X
1 LGG and HGG TTPmin 17.5 min 73% 67% - 70% *
1 LGG TAC - 71% 41% 0.549 X
1 LGG TAC change I to II/III 72% 89% - 78% *
1 LGG TBRmax + TTP + TAC change ∆ + 33% or ∆-6 min or I to II/III 83% 78% - 81% *
1 LGG TBRmax + TAC + TTP 1.6 + II/III + 25 min 65% 58% 0.634 X
1 LGG TBRmax + TAC 1.6 + II/III 65% 58% 0.639 X
1 LGG TBRmax + TTP 1.6 + 25 min 96% 25% 0.591 X
Recurrence vs. treatment-related changes
1 HGG Visual analysis Nodular vs. non-nodular 94% 94% NA
6 LGG SUVmax 1.48 88% 89% 0.951 *
LGG and HGG 1.66 87% 100% 0.978 *
HGG 93% 100% 0.993 *
LGG and HGG 2.2 100% 93% *
LGG and HGG - - *
LGG and HGG - - - X
1 LGG and HGG SUV80mean - - - X
1 LGG and HGG SUV-BG - - - X
20 LGG TBRmax 1.64 100% 75% 0.893 *
LGG and HGG 2 81% 60% 0.81 *
LGG and HGG - - X
LGG and HGG - - *
HGG 99% 94% 0.970 99% *
HGG 100% 78% NA
HGG 2.1 97% 91% NA
LGG and HGG 2.18 86% 88% 0.940 *
HGG 2.2 82% 95% NA
HGG 2.3 74% 98% NA
HGG 2.4 74% 100% NA
HGG 2.46 86% 100% 0.964 *
HGG 2.5 62% 100% NA
LGG and HGG 2.61 80% 86% 0.78 81% *
HGG 2.65 80% 88% *
HGG 2.85 64% 92% 0.75 78% *
HGG 3.44 86% 88% 0.86 *
HGG 3.58 64% 100% 0.84 *
HGG 3.69 79% 88% 0.86 *
LGG and HGG - - - - *
1 HGG TBRmax after 6 months - - - *
11 HGG TBRmean 1.8 96% 94% 0.977 96% *
HGG 1.9 74% 86% 0.86 77% *
HGG 1.95 82% 92% 0.77 87% *
HGG 100% 79% 0.89 83% *
HGG 75% 61% 0.73 68% *
LGG and HGG 2.0 74% 91% 0.91 75% *
HGG 82% 82% 0.91 82% *
HGG 2.19 71% 88% 0.80 *
HGG 2.31 61% 100% 0.83 *
LGG and HGG - - - 0.72 *
LGG and HGG - - - - *
1 LGG and HGG TBR30–40min 2.07 80% 85% 0.863 *
1 LGG and HGG TBR10–20min 1.71 76% 85% 0.848 *
1 HGG TBR10mm 2.86 86% 75% 0.81 *
8 HGG TBR16mm 1.9 84% 86% 0.88 85% *
LGG and HGG 1.95 70% 60% 0.72 68% *
HGG 100% 79% 0.89 83% *
HGG 2.25 81% 67% 0.79 74% *
LGG and HGG 2.3 68% 100% 0.85 71% *
HGG 100% 91% 0.94 96% *
HGG 2.44 82% 75% 0.82 *
LGG and HGG - - - 0.74 X
2 HGG TBR70% 2.72 86% 88% 0.87 *
LGG and HGG - - - *
2 HGG TBR80% 3.08 82% 88% 0.88 *
LGG and HGG - - - *
1 HGG TBR90% 3.23 71% 100% 0.85 *
1 LGG and HGG TBR80mean - - - *
8 LGG and HGG TTP 20 min 64% 79% 0.728 *
HGG 25 min 75% 44% 0.61 59% X
HGG 32.5 min 80% 69% 0.79 72% *
HGG 35 min 64% 83% 0.82 74% *
LGG and HGG 45 min 82% 73% 0.81 81% *
LGG and HGG - - - 0.60 X
LGG and HGG - - - 0.71 *
HGG - - - 0.86 - *
5 HGG Slope 0.02 SUV/h 73% 75% 0.72 74% X
HGG 0.3 SUV/h 56% 61% 0.55 59% X
HGG 0.32 SUV/h 70% 75% 0.82 74% *
LGG and HGG 0.69 SUV/h 84% 62% 0.69 80% *
LGG and HGG - - - 0.70 *
3 LGG and HGG TAC II/III 78% 73% - 77% *
HGG 84% 100% - 89% *
HGG - - - - *
1 HGG BTV 0.55 cm3 98% 94% 0.955 98% *
1 HGG BTV after 6 months - *
1 LGG and HGG TBRmean + TBRmax - 66% 80% 0.78 NA
1 HGG TBRmean + TBR16mm - 75% 72% - 74% *
1 HGG TBRmax + TTP 2.85 and 35 min 36% 100% 70% *
3 LGG and HGG TBRmean + TTP 2.0 and/or 45 min 93% 100% 93% *
HGG 1.95 and 35 min 55% 100% 78% *
HGG - 69% 78% - 74% *
2 LGG and HGG TBR16mm + TTP 2.3 and/or 45 min 92% 73% 90% *
HGG - 69% 83% 76% *
1 HGG TBR16mm/mean + TTP 1.95 and 32.5 min 89% 91% 90% *
1 HGG TBRmax+ TAC 2.3 and II/III 80% 91% 86% *
2 LGG and HGG TBRmean + TAC 2.0 and/or II/III 93% 73% 91% *
HGG 2.0 and II/III 60% 91% 76% *
1 LGG and HGG TBR16mm + TAC 2.3 and/or II/III 93% 73% 91% *
1 HGG TBRmean + Slope - 50% 78% 65% X
2 LGG and HGG TBR16mm + Slope 1.95 and/or 0.69 SUV/h 96% 43% 86% NA
HGG - 50% 89% 71% *
1 HGG TBR16mm/mean + Slope 1.95 and 0.32 SUV/h 78% 97% 93% *
1 HGG TTP + Slope - 56% 61% 59% X
1 HGG TBR16mm + TBRmean + TTP - 69% 89% 79% *
2 LGG and HGG Radiomics features - 73% 80% 0.85 NA
HGG - 100% 40% 0.74 70% *
1 LGG and HGG TBRmax + TBRmean + radiomics features - 81% 70% 0.85 NA
Prognosis/Treatment response evaluation
1 LGG Uptake Positive vs. negative - - X
1 LGG and HGG FET positivity Yes vs. no - - *
1 HGG New distant FET hotspot Yes vs. no *
1 LGG and HGG FET-PET response Yes vs. no - - *
3 LGG and HGG SUVmax/BG - - - X
LGG and HGG - - - X
LGG and HGG - - - X
1 LGG and HGG Initial SUVmax/BG - - - X
2 LGG SUVmean/BG - - - X
HGG - - - X
1 HGG SUVmean/BG pre re-RT 2.2 - - X
1 HGG SUVmean/BG post re-RT 2.3 - - X
1 LGG SUVtotal/BG - - - X
5 LGG and HGG SUVmax 2.3 - - X
LGG and HGG - - X
LGG and HGG 2.6 - - *
LGG and HGG 3.4 - - *
HGG Median - - X
1 HGG SUVmean Median - - X
1 HGG SUVpeak Median - - X
12 LGG and HGG TBRmax 1.6 - - X
LGG 2 - - X
HGG 2.4 - - *
LGG and HGG 2.5 - - 0.696 *
LGG and HGG 2.6 - - X
HGG 3 - - X
LGG and HGG 3.03 - - *
HGG Median (5.03) *
LGG - - - X
LGG and HGG - - - X
LGG and HGG - - - X
HGG - - - X
1 HGG TBRmax-preRCx 2.9 (OS) 68% 73% *
2 LGG and HGG TBRmax baseline 2.0 (PFS)/1.9 (OS) - - * (PFS)
HGG - - - NA
1 LGG and HGG TBRmax after 6 months - - - X
1 HGG Early TBRmax response ∆-10% - - *
1 LGG and HGG TBRmax response ∆ ± 10% - - *
3 LGG and HGG TBRmax change 0% - - *
HGG - - *
HGG ∆-10% (PFS)/∆-20% (OS) 83% (OS) 67% (OS) 0.75 (OS) *
1 HGG TBRmax pre re-RT 3.3 - - X
1 HGG TBRmax post re-RT 2.6 - - X
1 HGG TBR16mm relative reduction 27% 92% 63% 0.78 NA
1 HGG ∆TBRmax scan 2 - - - NA
1 HGG ∆TBRmax scan 3 - - - NA
2 HGG TBRmean 2 - - *
HGG 2.05 60% 70% 0.69 X
1 HGG TBRmean relative reduction 16% 92% 63% 0.81 NA
1 LGG and HGG TBR16mm baseline 1.9 (PFS)/1.8 (OS) - - X
3 LGG and HGG TBR16mm change 0% - - X
HGG - - X
HGG ∆-5% 67% 75% 0.72 *
1 HGG TBR in non-contrast enhancing tumor portions at follow-up High vs. low - - *
1 LGG TBR3SD 1.1 - - *
1 LGG and HGG TBR10mm 2.3 - - 0.696 *
1 HGG TBR16mm 2.55 70% 57% 0.63 X
5 HGG TBR 1.56 (PFS)/1.57 (OS) - - X
HGG 2 - - X
HGG 2.4 - - *
HGG 2.5 - - X
HGG Median - - X
1 HGG Early TBR response ∆-10% *
1 HGG TLG Median X
1 HGG TLU 35.0 (PFS)/17.1 (OS) - - * (OS)
1 LGG and HGG TTP 20 min - - 0.848 *
1 HGG 25 min 90% 87% 0.90 *
1 LGG and HGG - - - *
1 HGG TTP change 0% - - X
1 HGG TTPmin 12.5 min - - *
1 LGG and HGG >25 min vs. 12.5 < t ≤ 25 min vs. ≤12.5 min - - *
1 LGG and HGG 17.5 min - - *
1 HGG Slope −0.103 SUV/h 70% 90% 0.77 X
1 LGG and HGG - - - *
1 LGG and HGG Slope-to-peak 7 × 10−5/s - - 0.711 *
5 LGG TAC Increasing vs. decreasing - - *
LGG and HGG Homogeneous increasing vs. mixed vs. homogeneous decreasing - - *
LGG and HGG Homogeneous decreasing vs. focal decreasing vs. homogeneous increasing - - *
HGG Increasing - - *
LGG and HGG - - - *
1 HGG TAC pre re-RT G1–2 vs. G3 vs. G4–5 *
1 HGG TAC post re-RT G1–2 vs. G3 vs. G4–5 X
1 LGG and HGG Initial TAC Increasing vs. decreasing - - X
1 HGG Increasing vs. decreasing (OS) - - *
1 LGG and HGG TAC after 6 months Increasing vs. decreasing - - X
1 LGG and HGG TAC response Stable increasing vs. decreasing to increasing vs. Increasing to decreasing vs. Stable decreasing - - X
1 LGG and HGG Peak TBR 2.2 - - 0.704 *
8 HGG BTV 4.3 cm3 - - *
LGG and HGG 10 cm3 *
HGG 11.15 mL 72% 54% 0.56 X
HGG 19.4 (PFS)/18.9 (OS) - - * (OS)
HGG 20 mL - - *
HGG Median X
LGG - - - X
HGG - - - X
1 HGG BTVpreRCx 9.5 cm3 64% 70% *
1 LGG and HGG Initial BTV - - - X
1 LGG and HGG BTV baseline 28.2 mL (PFS)/13.8 mL (OS) - - *
1 HGG - - - *
1 LGG and HGG BTV after 6 months - - - *
1 HGG Absolute BTV at follow-up 5 mL 85% 88% 0.92 *
1 LGG and HGG BTV response ∆ ± 25% - - *
3 LGG and HGG BTV change 0% - - *
HGG 0% - - *
HGG 0% (PFS) - - - *
1 HGG BTV relative reduction 27% 77% 63% 0.82 NA
1 HGG ∆BTV scan 2 - - - X
1 HGG ∆BTV scan 3 - - - X
1 LGG and HGG BTVSUVmax≥2.2 - - - X
1 LGG and HGG BTV≥40%SUVmax - - - X
1 HGG BTVTBR≥ 1.6 25 mL - - *
1 HGG BTVTBR≥ 2.0 10 mL - - *
1 HGG BTV pre re-RT 13.7 cc - - X
1 HGG BTV post re-RT 7.3 cc - - X
Radiomic features: *
1 HGG  SUVmin - - - *, &
1 HGG  SUVmean - - - *, &
1 HGG  GLV - - - *, &
1 HGG  GLV2 - - - *, &
1 HGG  WF_GLV - - - *, &
1 HGG  Qacor - - - *, &
1 HGG  QHGZE - - - *, &
1 HGG  QSZHGE - - - *, &
1 HGG  QGLN2 - - - *, &
1 HGG  QHGRE - - - *, &
1 HGG  QSRHGE - - - *, &
1 HGG  QLRHGE - - - *, &
1 HGG  SZLGE - - - *
1 HGG  Busyness 1.366 (PFS)/0.984 (OS) - - *
1 HGG - - - *, &
1 HGG  WF_TS - - - *, &
1 HGG  QvarianceCM - - - *, &
1 HGG  Eccentricity - - - *, &
1 HGG  Coarseness 5.96 × 10−3 (PFS)/6.88 × 10−3 (OS) - - *
1 HGG  Contrast 0.427 - - *
1 HGG  Complexity 0.085 (PFS)/0.094 (OS) - - *
1 HGG  SUVmean + WF_GLV + QLRHGE + SUVmin - - - *
1 HGG  SZLGE + Busyness + QVarianceCM + Eccentricity - - - *