Table 3.
Biodistribution of [99mTc]Tc-DT11 in SCID mice bearing PC-3 xenografts at 4 h pi (controls, Entresto®-treated and block); data are expressed as average %IA/g values ± sd.
| Organs/Tissues | Block (n = 3) 1,2 | Controls (n = 4) 1 | Entresto® (n = 4) 1,3 |
|---|---|---|---|
| Blood | 0.52 ± 0.13 | 1.05 ± 0.30 | 0.53 ± 0.17 |
| Liver | 1.73 ± 0.13 | 1.39 ± 0.38 | 1.37 ± 0.24 |
| Heart | 0.21 ± 0.03 | 0.39 ± 0.18 | 0.17 ± 0.13 |
| Kidneys | 0.23 ± 0.17 | 2.87 ± 0.37 | 3.21 ± 0.62 |
| Stomach | 0.35 ± 0.20 | 0.38 ± 0.16 | 0.52 ± 0.20 |
| Intestines | 1.62 ± 0.52 | 1.91 ± 0.30 | 2.79 ± 0.62 |
| Spleen | 0.99 ± 0.30 | 0.89 ± 0.23 | 1.27 ± 0.39 |
| Muscle | 0.09 ± 0.03 | 0.16 ± 0.09 | 0.12 ± 0.03 |
| Lungs | 0.76 ± 0.15 | 1.03 ± 0.42 | 1.02 ± 1.17 |
| Pancreas | 0.14 ± 0.02 | 0.26 ± 0.09 | 0.21 ± 0.03 |
| PC-3 Tumor | 1.56 ± 0.43 | 4.23 ± 0.58 | 5.88 ± 1.47 |
1 Number of animals (n) are shown in parenthesis. 2 Mice co-injected with excess NT (100 µg) together with the radioligand. 3 Mice having received Entresto® (200 μL, 12 mg) per os 30 min in advance.