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Drugs’ mechanisms of action.
| Drug | Affinity | |||||
|---|---|---|---|---|---|---|
| SERT | DA | 5-HT | H | M | Others | |
| Fluoxetine | ||||||
| Prozac | H2 | α2, α3, β4 | ||||
| Fluoxetine hydrochloride | SERT | 5-HT2C | ||||
| Eli Lilly | ||||||
| Paroxetine | ||||||
| Seroxat | 5-HT1 | α1, α2, β | ||||
| Paroxetine hydrochloride | SERT | D2 | 5-HT2 | H1 | ||
| GlaxoSmithKline (GSK) | 5-HT3 | |||||
| Sertraline | ||||||
| Zoloft | σ1 | |||||
| Sertraline hydrochloride | SERT | |||||
| Pfizer | ||||||
| Citalopram | ||||||
| Cipramil | ||||||
| Citalopram hydrobromide | SERT | |||||
| Lundbeck | H1 | |||||
| Escitalopram | ||||||
| Lexapro | 5-HT1A | M1 | ||||
| Escitalopram oxalate | SERT | D2 | 5-HT2A | H1 | ||
| Lundbeck | 5-HT2C | α2 | ||||
