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. 2024 Sep 12;17(9):1204. doi: 10.3390/ph17091204

Figure 4.

Figure 4

IMD up-regulates CPT-1β. RNA-sequencing analysis of hearts in mice. (A) Volcano plot showing the transcript expression profiles of differentially expressed genes in the hearts of the WT diabetic mice, respectively. n = 3. (B) KEGG pathway enrichment analysis showing the 20 most significantly enriched signaling pathways for differentially expressed genes in the hearts of WT diabetic mice. n = 3. (C) Heat map of the microarray results showing the 36 (ranked by p-values) differentially expressed fatty acid metabolism genes in hearts from the WT diabetic mice. Red, up-regulated; blue, down-regulated; white, no change. n = 3. (D) Quantitative real-time PCR analysis of Cpt1b mRNA expression in the hearts of WT diabetic mice and diabetic rats. n = 4. (E) Volcano plot showing the transcript expression profiles of differentially expressed genes in the hearts from the diabetic WT and IMD−/− mice, respectively. n = 3. (F) KEGG pathway enrichment analysis showing the 20 most significantly enriched signaling pathways for differentially expressed genes in the hearts of diabetic WT and IMD−/− mice. n = 3. (G) Heat map of the microarray results showing the 28 (ranked by p-values) differentially expressed fatty acid metabolism genes in hearts from the diabetic WT and IMD−/− mice. Red, up-regulated; blue, down-regulated; white, no change. n = 3. (H) Quantitative real-time PCR analysis of Cpt1b mRNA expression in the hearts of diabetic WT and IMD−/− mice. n = 4. (I) Heat map of the microarray results showing the 23 (ranked by P-values) differentially expressed fatty acid metabolism genes in hearts from the diabetic WT and IMDtg mice. Red, up-regulated; blue, down-regulated; white, no change. n = 3. (J) Quantitative real-time PCR analysis of Cpt1b mRNA expression in the hearts of diabetic WT and IMDtg mice. n = 4. Data are mean ± SD, ** p < 0.01.