Table 1.
IC50 values of the indicated compounds in human NSCLC cell lines (blue, cell lines without KRAS mutations; orange, cell lines with KRAS mutations). Values indicate mean IC50 ± span (μM). Average IC50 values across the cell lines of the same group are displayed for each compound; 48 h treatments in MTT assay; N.D. = not determined.
| # | H522 | H661 | H1395 | H1993 | IC50 * | H157 | A549 | H460 | H1792 | HCC-44 | H1355 | IC50 * | IMR90 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 75 ± 0.89 | 47 ± 1.1 | 47 ± 0.4 | 37 ± 1.3 | 52 | N.D. | >100 | 52 ± 1.2 | 60 ± 1.4 | 45 ± 0.25 | 41 ± 0.33 | 62 | N.D. |
| 2 | 53 ± 2.1 | 45 ± 1.7 | 17 ± 0.8 | 6.1 ± 0.76 | 30 | N.D. | 56 ± 1.6 | 65 ± 2.2 | 24 ± 0.98 | 26 ± 1.3 | 34 ± 1.4 | 41 | N.D. |
| 3 | 15 ± 1.1 | 27 ± 1.2 | 11 ± 0.63 | 11 ± 0.96 | 16 | N.D. | 91 ± 1.03 | 68 ± 0.10 | 50 ± 1.2 | 10 ± 1.1 | 9.1 ± 1.03 | 46 | N.D. |
| 4 | 5.3 ± 0.88 | 7 ± 0.81 | 11 ± 0.88 | 12 ± 1.03 | 9 | N.D. | 19 ± 1.0 | 11 ± 1.2 | 16 ± 0.94 | 14 ± 1.1 | 8.1 ± 0.66 | 14 | N.D. |
| 5 | 52 ± 0.37 | 42 ± 1.7 | 49 ± 0.11 | 70 ± 1.6 | 53 | N.D. | 49 ± 0.33 | >100 | >100 | 32 ± 1.6 | 12 ± 0.72 | 59 | N.D. |
| 6 | 55 ± 1.9 | 26 ± 1.5 | 62 ± 2.4 | 5.6 ± 0.76 | 37 | N.D. | 13 ± 1.03 | 37 ± 1.8 | 15 ± 1.1 | 19 ± 1.4 | 59 ± 1.7 | 29 | N.D. |
| 7 | 6.5 ± 0.97 | 0.95 ± 1.0 | 6.3 ± 0.98 | 1.8 ± 0.96 | 4 | 8.5 ± 1.2 | 16 ± 1.3 | 6.6 ± 1.02 | 12 ± 1.04 | 9.2 ± 1.02 | 7.8 ± 0.61 | 10 | 63 ± 2.5 |
| 8 | 3.3 ± 0.93 | 1.1 ± 1.1 | 5.9 ± 0.97 | 1.8 ± 1.05 | 3 | 17 ± 1.2 | 9.1 ± 1.2 | 13 ± 1.4 | 15 ± 1.1 | 7.3 ± 1.05 | 6.4 ± 0.65 | 11 | 87 ± 4.9 |
* Averaged values.