Table 2.

Variation and statistics of the TxrR activity in H522 and A549 lung cancer cell lysates collected after 24 h of treatment (5 μM). The reduction of DTNB into TNB (OD₄₁₂) was measured at 25, 60, 90, and 110 min. Two-way ANOVA followed by Dunnett’s multiple comparisons with ns = p > 0.05; * = p > 0.05; ** = p > 0.01; *** = p > 0.001 and **** = p > 0.0001.

Dunnett’s Comparison	H522				A549
	Mean Diff.	95.00% CI of Diff.	Summary	Adj p Value	Mean Diff.	95.00% CI of Diff.	Summary	Adj p Value
25 min
1 vs. veh	15.84	−6.504 to 38.19	ns	0.2655	−16.73	−32.31 to −1.152	*	0.0306
2 vs. veh	3.864	−18.48 to 26.21	ns	0.9981	−5.148	−20.73 to 10.43	ns	0.918
3 vs. veh	−44.05	−66.40 to −21.70	****	<0.0001	−21.88	−37.46 to −6.300	**	0.0027
4 vs. veh	23.18	0.8373 to 45.53	*	0.0391	−3.861	−19.44 to 11.72	ns	0.9819
5 vs. veh	−35.55	−57.90 to −13.20	***	0.0006	−11.58	−27.16 to 3.996	ns	0.2233
6 vs. veh	−31.68	−54.03 to −9.338	**	0.0024	−17.37	−32.95 to −1.795	*	0.023
7 vs. veh	−57.19	−79.53 to −34.84	****	<0.0001	−59.2	−74.78 to −43.62	****	<0.0001
8 vs. veh	−81.92	−104.3 to −59.57	****	<0.0001	−86.87	−102.5 to −71.29	****	<0.0001
60 min
1 vs. veh	−8.894	−31.24 to 13.45	ns	0.8206	−13.1	−28.68 to 2.479	ns	0.1319
2 vs. veh	−19.16	−41.50 to 3.190	ns	0.1201	−11.64	−27.22 to 3.934	ns	0.2189
3 vs. veh	−47.07	−69.42 to −24.72	****	<0.0001	−4.221	−19.80 to 11.36	ns	0.97
4 vs. veh	7.116	−15.23 to 29.46	ns	0.9312	−2.183	−17.76 to 13.40	ns	0.9996
5 vs. veh	−39.68	−62.03 to −17.34	***	0.0001	−29.11	−44.69 to −13.53	****	<0.0001
6 vs. veh	−37.22	−59.57 to −14.87	***	0.0003	−2.183	−17.76 to 13.40	ns	0.9996
7 vs. veh	−91.41	−113.8 to −69.06	****	<0.0001	−44.4	−59.97 to −28.82	****	<0.0001
8 vs. veh	−82.1	−104.4 to −59.75	****	<0.0001	−80.79	−96.36 to −65.21	****	<0.0001
90 min
1 vs. veh	−20.1	−42.44 to 2.252	ns	0.0938	−26.55	−42.13 to −10.98	***	0.0002
2 vs. veh	−23.38	−45.73 to −1.037	*	0.0368	−22.67	−38.25 to −7.090	**	0.0018
3 vs. veh	−47.31	−69.66 to −24.97	****	<0.0001	−8.42	−24.00 to 7.159	ns	0.5454
4 vs. veh	−0.3654	−22.71 to 21.98	ns	>0.9999	−18.13	−33.71 to −2.556	*	0.0163
5 vs. veh	−41.1	−63.45 to −18.76	****	<0.0001	−31.74	−47.31 to −16.16	****	<0.0001
6 vs. veh	−39.82	−62.17 to −17.48	***	0.0001	−31.09	−46.67 to −15.51	****	<0.0001
7 vs. veh	−90.61	−113.0 to −68.26	****	<0.0001	−56.35	−71.93 to −40.77	****	<0.0001
8 vs. veh	−91.89	−114.2 to −69.54	****	<0.0001	−82.25	−97.83 to −66.68	****	<0.0001
110 min
1 vs. veh	−23.89	−46.24 to −1.545	*	0.0316	−32.38	−47.96 to −16.80	****	<0.0001
2 vs. veh	−31.46	−53.80 to −9.111	**	0.0026	−30.44	−46.02 to −14.86	****	<0.0001
3 vs. veh	−50.17	−72.52 to −27.83	****	<0.0001	−9.068	−24.65 to 6.512	ns	0.4662
4 vs. veh	−18.72	−41.06 to 3.631	ns	0.1345	−21.37	−36.95 to −5.794	**	0.0034
5 vs. veh	−45.26	−67.61 to −22.91	****	<0.0001	−33.68	−49.26 to −18.10	****	<0.0001
6 vs. veh	−46.06	−68.40 to −23.71	****	<0.0001	−38.86	−54.44 to −23.28	****	<0.0001
7 vs. veh	−89.86	−112.2 to −67.51	****	<0.0001	−53.76	−69.34 to −38.18	****	<0.0001
8 vs. veh	−88.27	−110.6 to −65.92	****	<0.0001	−82.25	−97.83 to −66.68	****	<0.0001