Table 1.
Distribution of NAT2 haplotypes and their gene product acetylator phenotype in 502 breast cancer patients
Acetylator phenotype | Haplotype | References | ||
Status | No. | % | ||
Fast | 24 | 4.8 | NAT2*4/NAT2*4 | 31–34 |
Intermediate | 158 | 31.5 | All intermediate | 14 |
148 | 93.7 | NAT2*4/- | 35 | |
10 | 6.3 | NAT2*12a/- | ||
Slow | 320 | 63.7 | All slow | 14,33,36 |
81 | 24.6 | NAT2*5b/NAT2*5b | ||
139 | 43.4 | NAT2*5b/NAT2*6a | ||
37 | 11.2 | NAT2*5b/- | 14,31–33,36 | |
43 | 13.1 | NAT2*6a/NAT2*6a | ||
18 | 6.1 | NAT2*6a/- | 14,36,37 | |
2 | 3.3 | NAT2*5c/- |
-, any other haplotype yielding heterozygosity; NAT, N-acetyltransferase.