TABLE II.

Literature summary of nanoparticle synthesis using supercritical ${\mathrm{CO}}_2$ in microfluidics.

Microfluidic		Size	Pressure	Temperature
design	Nanoparticle	(nm)	(MPa)	(°C)	Reference
Co-flow	Palladium (Pd) nanocrystal	3.6 ± 0.6	25	100	Gendrineau et al.49
Co-flow	Poly(3-hexylthiophene) (P3HT) nanoparticle	36 ± 8	10	40	Couto et al.50
		47 ± 12	8	50
Co-flow	Tetraphenylethylene (TPE) nanoparticle	9 ± 3	10	40	Jaouhari et al.80
Co-flow	Fluorescent organic nanoparticle	16 ± 4	10	40	Jaouhari et al.46
T-junction	Polyvinyl alcohol (PVA) nanoparticle	10–20a	8.5–12	36.85	Murakami and Shimoyama51
T-junction	Ibuprofen/PVA nanoparticleb	231 ± 31	8.5–12	36.85	Murakami and Shimoyama52
T-junction	Timolol maleate (TM)-loaded liposome	80–3000c	10	40	Murakami et al.54
T-junction	PEGylated liposome	270–417d	10	40	Akiyama et al.53
T-junction	Stearic acid solid lipid nanopariticle	20–150e	8.5–20	40	Wijakmatee et al.81

^a Depending on the degree of PVA hydrolyzed.

^b Ibuprofen/PVA nanoparticles were functionalized by chitosan.

^c Depending on the co-solvent (ethanol) flow rate.

^d Depending on the ratio of PEG:lipid.

^e Depending on the pressure and total flow rate of water and oil phases.