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Triple LTM example. Nine amino acids, representative of the 20, were selected for the LTM process based on their side-chain chemical functionalities (Inset Left). Discrete CDR oligonucleotides are synthesized to produce a mutagenized CDR with one target amino acid mutation at each CDR position (Inset Right). In the triple CDR library, all combinations of CDR1, CDR2, and CDR3 oligonucleotides are combined to produce libraries with three simultaneously mutagenized CDRs.
