Table 2.
Mixture associations using weighted quantile sum (WQS) regression.
| Outcome | All | Boys | Girls |
|---|---|---|---|
| IRR or PC (95% CI) | IRR or PC (95% CI) | IRR or PC (95% CI) | |
| Total CBCL score | 1.09 (0.96, 1.23) | 1.07 (0.91, 1.25) | 1.11 (0.90, 1.35) |
| Externalizing score | 1.15 (0.97, 1.36) | 1.20 (0.96, 1.49) | 1.11 (0.88, 1.39) |
| Internalizing score | 1.03 (0.90, 1.17) | 1.04 (0.85, 1.29) | 1.00 (0.76, 1.30) |
| Urinary BDNF levels | 25.9 (17.6, 34.7) | 36.0 (24.3, 48.9) | 18.6 (7.92, 30.5) |
Note: Sample size for CBCL was 298, 149 for boys and 149 for girls, respectively. Sample size for urinary BDNF was 1148 in total, 570 and 578 for boys and girls, respectively (since NEBII-NO participants had data on MHINCH but not MCOCH, mixture models only included the MHINCH metabolite). Mixture models between phthalate exposure and serum BDNF in the CRP-SLO cohort were not computed due to the limited sample size available. The incidence rate ratio (IRR) or percentage change (PC) represents the mean change in CBCL score or BDNF levels per tertile increase of the mixture, with its related 95% confidence interval (95% CI). The weight contributed by each chemical compound to the most relevant mixture associations can be consulted in Supplementary Figure S2. Mixture models were adjusted for the same set of covariates considered in single-pollutant analyses.