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Surface model of the core structure of HIV-1 gp120 (gray) bound to a ribbon diagram of CD4 (green). Deletion mutations (blue) in the V4 loop and point mutations (red) as a consequence of HIV resistance development to CV-N result in the loss of glycosylation sites in the gp120 envelope glycoprotein. The red arrow indicates the point mutation at residue 302 near the V3 loop that abolishes an important glycosylation site from the gp120 molecule.
