FIGURE 2.

Differences between food specific and microbe specific pTregs. Dietary antigens presented by CD103⁺ classical dendritic cells 1 (cDC1) to antigen specific CD4⁺ T cells, mediate the formation of Foxp3⁺ RORgt^- pTregs in duodenal draining lymph nodes. The food specific pTregs migrate to the small intestine lamina propria where they undergo expansion. Microbe induced Foxp3⁺RORγt⁺ pTregs are formed in the colon draining lymph nodes through antigen-presentation by RORγt⁺ antigen presenting cells (APC). These MHCII⁺RORγt⁺ APC include ILC3s, AIRE⁺ APCs, and DC-like APC referred. Microbe induced pTregs preferentially home to the colonic lamina propria.