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. 2024 Aug 3;38(10):2183–2195. doi: 10.1038/s41375-024-02351-2

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Heatmap visualizing the percentage of leukemic blasts, defined as CD45^dim cells within the BM of pediatric AML patients (n = 30), expressing the target antigens CD33, CD38, CD123, CD135, CD371, CD276, IL1RAP, Mesothelin, or MIC A/B as well as CD34, analyzed by flow cytometry. Patients are grouped by primary disease vs. relapse as well as FAB classification/MDS-EB. Target expression of the used AML cell lines are visualized as heatmap next to patient data (right). Comparison of target antigen expression between AML blasts and major cell populations (defined as follows: HSC (CD45^dim/CD34^high/CD38^low), HSPC (CD45^dim/CD34^high/CD38^high), lymphocytes (CD45^high/SSC^low), T cells (CD45^high/SSC^low/CD3^high), and monocytes (CD45^high/SSC^median)) in bone marrow from healthy donors (n = 5). In B the percentage of antigen-positive cells is provided; in C the mean fluorescence intensity difference (MFID). Each data point represents an individual patient or heathy donor, and horizontal lines represent the mean value ± standard deviation (SD).