Table 2.

DRD2 in breast and lung cancers

System	Agents/targets	Results/effect
Breast cancer
MCF-7 cells	bromocriptine (DRD2 agonist)	proliferation ↓	[31]
Xenograft mice	sulpiride (DRD2 antagonist)	anticancer effect	[32]
MDA-MB-231, MCF-7, and SKBR3 cells	Mir-4301 (DRD2 downregulation)	apoptosis	[27]
MDA-MB231 and BT549 cells/Mice	DRD2 expression	apoptosis	[33]
Lung cancer
Human	SNP study	DRD2 and nicotine addiction	[34]
Xenograft mice	bromocriptine	proliferation ↓	[35]
Xenograft mice	DRD2 agonist	Cancer angiogenesis ↓	[36]
NSCLC	DRD2 overexpression	Tumor cell growth ↓	[38]